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Table 3 The 56-gene profiles in cancerous cells/tissues strongly deviate from that in the normal counterpart

From: Tissue-specific gene expression templates for accurate molecular characterization of the normal physiological states of multiple human tissues with implication in development and cancer studies

NCI60 cell lines

Tissue/Cell line

Prediction Accuracya

Correlation Coefficientb

Lung (n = 8)

3 (37.5%)

0.21 ± 0.12

Ovary (n = 8)

0(0%)

0.15 ± 0.08

Prostate (n = 2)

0(0%)

0.05 ± 0.04

Kidney (n = 8)

7(87.5%)

0.43 ± 0.15

Skin ((n = 10)

0 (0%)

0.017 ± 0.05

Skin-GSE3189

Normal skin (n = 7)

7 (100%)

0.78 ± 0.05

Benign nevus (n = 18)

17 (94.4%)

0.73 ± 0.06

Melanoma (n = 45)

5 (11.11%)

0.36 ± 0.14

  1. a Tissue prediction was as described in Methods by comparing the c.f. between the 56-gene profiles of the test against each of our 24 training tissues.
  2. b The c.f. exhibited here is that between the 56-gene profiles of the test and the corresponding normal tissue in our training set.
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BMC Genomics

ISSN: 1471-2164

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