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Table 3 The 56-gene profiles in cancerous cells/tissues strongly deviate from that in the normal counterpart

From: Tissue-specific gene expression templates for accurate molecular characterization of the normal physiological states of multiple human tissues with implication in development and cancer studies

NCI60 cell lines
Tissue/Cell line Prediction Accuracya Correlation Coefficientb
Lung (n = 8) 3 (37.5%) 0.21 ± 0.12
Ovary (n = 8) 0(0%) 0.15 ± 0.08
Prostate (n = 2) 0(0%) 0.05 ± 0.04
Kidney (n = 8) 7(87.5%) 0.43 ± 0.15
Skin ((n = 10) 0 (0%) 0.017 ± 0.05
Skin-GSE3189
Normal skin (n = 7) 7 (100%) 0.78 ± 0.05
Benign nevus (n = 18) 17 (94.4%) 0.73 ± 0.06
Melanoma (n = 45) 5 (11.11%) 0.36 ± 0.14
  1. a Tissue prediction was as described in Methods by comparing the c.f. between the 56-gene profiles of the test against each of our 24 training tissues.
  2. b The c.f. exhibited here is that between the 56-gene profiles of the test and the corresponding normal tissue in our training set.