Figure 4From: Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samplesSources of dataset variance. (A) Cluster dendrogram of average linkage showing similarities between assays and tissue types. Samples tended to cluster by assay type (IVT/DASL) and preservation style (Frozen/Fixed). (B) To quantify the effects of these predictors on the variance in the dataset, MDMR analysis was conducted. Single and multiple regression MDMR analysis are shown. Assay (IVT/DASL), source (Frozen/Fixed), batch, diagnosis, age, and gender of case from which tissue samples were taken were assessed. In the single regression model, each predictor is assessed separately; in the multiple regression model, each predictor is tested in relation with the other predictors in the model, yielding a cumulative percent variance explained (PVE).Back to article page