Table 7 Putative P. larvae antibiotic resistance proteins based on matches to conserved domains

EFX43850 (3E-37),

EFX47127 (3E-26),

EFX43889 (2E-44),

ABC_BcrA_bacitracin_resist [cd03268]: The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance; bacitracin is an antibiotic produced by B. licheniformis and B. subtilis with potent antibiotic activity against gram-positive bacteria

EFX46602 (1E-57),

EFX44842 (2E-50),

EFX46272 (4E-41),

EFX45233 (9E-52)

EFX46614 (4E-25),

ABC_DR_subfamily_A [cd03230]: This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity

EFX44699 (4E-16),

EFX45065 (1E-50)

ABC_DrrA [cd03265]: DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin

EFX46465 (1E-55),

ABC_drug_resistance_like [cd03264]: ABC-type multidrug transport system, ATPase component

EFX45467 (3E-61),

EFX45475 (2E-48*)

EFX43892 (1E-42),

ABC_putative_ATPase [cd03269]: This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity

EFX46872 (1E-35),

EFX47099 (4E-20*),

EFX45045 (1E-71*)

EFX46236 (3E-6*)

ABCC_MRP_Like [cd03228]: The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export; they belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins.

EFX44443 (3E-26)

ACR_tran [pfam00873]: AcrB/AcrD/AcrF family. Members of this family are integral membrane proteins. Some are involved in drug resistance

EFX44702 (4E-33),

CcmA [COG1131]: ABC-type multidrug transport system, ATPase component

EFX46006 (5E-34),

EFX44595 (4E-16),

EFX43880 (8E-54),

EFX47052 (7E-40),

PL1_2983 (1E-33),

EFX46146 (6E-40),

EFX45253 (3E-22),

EFX45810 (9E-18),

EFX45945 (1E-18),

EFX47082 (9E-21*),

EFX44360 (3E-15*),

EFX46805 (6E-30*),

EFX45180 (5E-27*)

EFX43881 (3E-4*)

COG0842 [COG0842]: ABC-type multidrug transport system, permease component

EFX44713 (1E-52)

COG2409 [COG2409]: Predicted drug exporters of the RND superfamily

EFX47096 (4E-18)

COG4152 [COG4152]: ABC-type uncharacterized transport system, ATPase component

EFX46793 (6E-34)

COG4586 [COG4586]: ABC-type uncharacterized transport system, ATPase component

EFX46612 (2E-58),

drrA [TIGR01188]: daunorubicin resistance ABC transporter ATP-binding subunit

EFX43786 (8E-63),

EFX45226 (4E-54),

EFX44634 (3E-36*)

EFX43785 (4E-5)

drrB [TIGR01247]: daunorubicin resistance ABC transporter membrane protein; the protein associated with effux of the drug, daunorubicin

EFX44398 (8E-11),

EFX47139 (1E-59)

efflux_Bcr_CflA [TIGR00710]: drug resistance transporter, Bcr/CflA subfamily

EFX46169 (4E-40),

efflux_EmrB [TIGR00711]: drug resistance transporter, EmrB/QacA subfamily

EFX44387 (7E-37),

EFX44446 (8E-09),

EFX46307(5E-24),

EFX46126 (1E-53),

EFX44956 (3E-9*)

EFX46708 (3E-14)

emrE [PRK09541]: multidrug efflux protein

EFX44177 (2E-4*)

Glyoxalase [pfam00903]: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

EFX45543 (4E-10),

HTH_MARR [smart00347]: helix_turn_helix multiple antibiotic resistance protein

EFX43861 (8E-11),

EFX46148 (6E-10),

EFX46170 (4E-12),

EFX44712 (3E-12),

EFX45783 (3E-6*),

EFX46306 (1E-8*),

EFX46227 (3E-4*),

EFX44716 (5E-9*)

EFX45439 (2E-48)

Lant_dehyd_C [pfam04738]: Lantibiotic dehydratase, C terminus

EFX45438 (3E-31)

LanC [cd04793]: LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics

EFX46802 (4E-77*),

EFX46803 (4E-12*)

LcnDR2 [COG4403]: Lantibiotic modifying enzyme

EFX45784 (1E-84),

MdlB [COG1132]: ABC-type multidrug transport system; ATPase and permease components

EFX45333 (6E-107),

EFX44415 (7E-47*),

EFX44416 (5E-44*),

EFX45434 (1E-26*)

EFX45348 (3E-36)

NorM [COG0534]: Na+-driven multidrug efflux pump

EFX45532 (1E-114)

PRK01766 [PRK01766]: multidrug efflux protein

EFX46249 (6E-16)

PRK03545 [PRK03545]: sugar efflux transporter

EFX46262 (2E-15),

EFX44433 (8E-82)

PRK09874 [PRK09874]: drug efflux system protein MdtG

EFX45329 (5E-21)

PRK10054 [PRK10054]: putative MFS-type transporter YdeE

EFX47111 (5E-4*)

PRK10504 [PRK10504]: multidrug efflux system protein MdtE

EFX45115 (3E-58*)

PRK10522 [PRK10522]: multidrug transporter membrane component/ATP-binding component

EFX47080 (1E-129)

PRK10789 [PRK10789]: putative multidrug transporter membrane\ATP-binding components

EFX47079 (5E-98)

PRK10790 [PRK10790]: putative multidrug transporter membrane\ATP-binding components

EFX45606 (2E-13)

PRK11102 [PRK11102]: bicyclomycin/multidrug efflux system

EFX46841 (4E-19),

EFX46842 (3E-13)

PRK11431 [PRK11431]: quaternary ammonium compound-resistance protein SugE

EFX43805 (8E-7*)

PRK11646 [PRK11646]: multidrug resistance protein MdtH

EFX47100 (4E-6)

RND_mfp [TIGR01730]: RND family efflux transporter, MFP subunit