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Table 2 Apoptosis and cell survival genes responsive to MYC-ERTAM activation

From: Deciphering c-MYC-regulated genes in two distinct tissues

   Pancreatic β-Cells Suprabasal Keratinocytes  
Gene Symbol RefSeq 4 Hours 8 Hours 16 Hours 32 Hours 4 Hours 8 Hours 16 Hours 32 Hours Myc-response p-value
Apoptosis           
bax BC018228 1.09 1.65** 2.49** 1.72** 1.37* 1.70** 1.87** 1.99** 4.61E-02
birc4 BF134200 0.52* 0.64 1.76 1.77* 0.71 0.72 0.77 1.10 3.12E-02
birc4 BF134200 0.69* 0.58* 0.78 0.81 0.53** 0.31** 1.14 0.75 5.29E-03
birc5 BC004702 0.57* 1.99** 16.53** 1.90** 0.61** 1.13 1.06 1.25 8.88E-03
cdc2a NM_007659 0.95 2.91** 11.93** 3.35** 0.51* 1.17 0.89 1.12 4.33E-02
cdkn2a NM_009877 2.17** 1.79** 1.57** 2.61** 1.21 1.07 1.07 0.87 8.43E-03
cflar BE284491 1.03 0.97 1.00 0.94 1.04 1.00 1.28** 2.34** 4.59E-02
cflar BE284491 0.82* 0.87 0.54** 0.43** 1.00 1.13 1.03 1.09 2.22E-02
cflar AK020765 0.78* 0.75* 1.18 0.51** 1.05 1.16 1.01 0.73* 4.40E-02
cycs NM_007808 0.96 0.87 2.54** 2.38** 0.99 1.62** 0.96 0.91 2.84E-02
cycs NM_007808 1.17* 1.98** 1.55** 2.05** 0.83* 1.00 1.17 1.05 1.64E-03
d2wsu81e AV104666 2.85** 2.94** 1.50** 1.85** 0.74* 1.01 0.95 1.24 1.19E-05
endog NM_007931 2.49** 2.90** 2.40** 1.96** 0.75* 1.46** 1.20 1.74** 2.48E-02
fas BG976607 6.55** 6.15** 3.85** 11.34** 0.82 1.22 1.61 1.35 3.79E-02
fas BG976607 3.61** 7.00** 1.13 4.43** 1.33 0.63 1.35 0.46** 6.32E-03
fas BG976607 5.08** 12.85** 5.07** 10.92** 0.72 5.14** 0.74 0.48* 1.12E-03
fas BG976607 2.43** 1.78** 2.28** 2.50** 0.83 1.33 1.09 0.39** 2.21E-03
ing3 BB298005 0.9 1.12 1.15 0.66** 0.79 0.49** 0.77* 1.34* 1.50E-02
pmaip1 NM_021451 1.15 1.13 1.02 0.85 1.33* 0.45** 0.77* 0.87 6.77E-03
tnfrsf12a NM_013749 0.59** 0.85 2.53** 0.72** 1.11 3.15** 1.38** 1.17 4.16E-02
tnfrsf12a NM_013749 0.86 0.87 2.29** 0.85 1.18 2.77** 1.39** 1.11 4.89E-03
tnfrsf4 NM_011659 1.18 0.60* 1.46* 1.64** 1.27 2.12** 1.76** 1.03 5.78E-03
Cell Survival           
akt1 NM_009652 1.01 0.97 1.71** 2.31** 0.82 3.23** 0.95 2.29** 4.43E-02
akt2 NM_007434 1.00 1.05 0.98 1.13 1.27 2.21** 1.02 2.26** 7.85E-03
akt2 BC026151 0.78 0.89 2.31** 2.69** 0.99 1.74** 1.01 1.70** 3.97E-02
igf1 NM_010512 2.08* 0.63 0.74 1.20 1.17 2.33** 1.47 2.00* 4.75E-02
igf1 BG075165 0.97 1.11 1.25 2.11** 1.03 1.09 2.34** 3.54** 4.66E-02
igf1 AF440694 1.05 1.00 1.59 3.71** 1.56* 2.24** 1.24 3.08** 4.10E-02
DNA-damage           
atm NM_007499 0.84 0.43** 1.12 1.08 0.90 0.92 1.46 0.60* 1.62E-04
atr AF236887 2.25** 3.79** 2.71** 2.76** 1.17 1.17 1.44* 1.53** 3.46E-02
chek1 BB298208 1.10 3.70** 2.35** 1.92** 0.91 1.03 1.31 1.23 4.05E-03
chek1 C85740 1.94* 4.38** 4.71** 4.17** 0.90 0.48* 1.28 1.03 1.62E-02
chek1 NM_007691 1.37 1.79* 3.16** 1.73** 0.74 0.88 1.38 1.33 5.83E-03
chek2 NM_016681 1.24 2.07** 2.65** 2.29** 0.82 0.63* 1.13 1.34 1.98E-02
gadd45g AK007410 0.59* 0.41** 1.88** 0.59** 4.07** 5.16** 3.39** 2.78** 5.95E-03
h2afx NM_010436 1.17 2.17** 4.56** 1.40** 0.67** 1.22* 0.97 1.01 3.43E-03
hus1 NM_008316 0.85 1.97** 2.04** 1.62** 0.97 0.96 1.24 1.23 1.46E-02
hus1 AF076845 1.37 1.05 2.12** 1.29 1.02 1.06 1.07 1.24 1.85E-02
rad1 NM_011232 2.12** 2.27** 2.13* 1.58 0.67 3.18** 0.79 1.94* 3.77E-03
rad51 NM_011234 1.02 6.19** 23.30** 2.40** 0.82 1.12 1.90** 1.46 1.80E-02
  1. Selected MYC-responsive genes relating to apoptosis and cell survival. 'MYC-response p-value' is the p-value identified for the highest-order interaction of the MYC activation variable and represents the significance of this term within the selected model. Flags represent contrast p-values comparing 4OHT-treated and vehicle-treated samples at specific time points ('*', p ≤ 0.05; '**' p ≤ 0.01). Cells are colour-coded based on a detected fold-change greater than 1.5-fold (red, up-regulated; blue, down-regulated).