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Table 3 Differentiation, angiogenesis, and cellular adhesion genes responsive to MYC-ERTAM activation

From: Deciphering c-MYC-regulated genes in two distinct tissues

   Pancreatic β-Cells Suprabasal Keratinocytes  
Gene Symbol RefSeq 4 Hours 8 Hours 16 Hours 32 Hours 4 Hours 8 Hours 16 Hours 32 Hours Myc-response p-value
Differentiation           
adamts1 D67076 0.56 0.72 2.12* 1.10 1.42 1.33 3.29** 3.42** 2.89E-02
creg1 BC027426 2.08** 2.12** 1.60** 2.16** 0.69* 0.85 0.98 0.92 3.68E-02
csta C89521 1.12 1.13 1.04 0.88 0.49** 1.04 0.34** 0.52** 1.28E-02
eg666231 C81193 1.26* 1.85** 2.40** 1.98** 0.82* 2.76** 1.19 2.29** 1.94E-02
gck L38990 0.59* 0.14** 2.46** 0.81 1.14 1.41 1.27 1.29 2.31E-03
ins1 NM_008386 0.18* 0.42 9.94** 10.18** 1.55 1.14 1.46 1.26 1.80E-03
ins2 NM_008387 0.17* 0.36 8.70** 12.66** 0.57 1.36 1.00 0.77 1.03E-03
ivl AV009441 0.99 1.24 1.06 1.03 0.35** 0.59** 0.22** 0.82 4.32E-02
krt1 NM_008473 1.49* 0.99 1.17 1.02 0.48** 4.02** 0.70* 0.86 4.05E-02
krt14 BC011074 1.26 1.43* 1.16 0.73* 0.89 2.02** 0.96 0.98 1.93E-02
krt14 BC011074 1.12 1.00 1.16 0.98 0.91 2.17** 0.89 1.04 2.87E-02
mnx1 NM_019944 0.57* 0.40** 0.88 1.40 0.88 1.03 1.06 0.96 1.07E-02
nkx2-2 NM_010919 0.65 0.66* 1.55 0.43** 0.91 0.76 0.97 0.65* 2.22E-02
nkx6-1 AF357883 0.53* 0.32** 2.29** 1.13 0.91 0.94 1.09 0.98 4.29E-02
odc1 S64539 1.72** 2.29** 1.83** 1.82** 1.11 1.62** 0.99 1.81** 2.43E-02
pcnt NM_008787 2.70** 3.79** 5.22** 4.18** 1.14 1.89** 1.1 1.82** 1.37E-02
pcsk2 BB357975 2.24** 0.56* 0.69* 1.08 1.24 1.12 1.04 0.83 1.33E-02
pcsk2 AI839700 0.98 0.48** 0.71** 0.93 1.03 1.08 0.89 0.89 3.31E-02
pcsk2 NM_008792 0.42** 0.39** 1.74** 2.59** 0.94 1.01 1.10 0.96 4.15E-02
pdx1 AK020261 0.74* 0.20** 0.71* 0.47** 1.96** 1.11 1.30 0.95 3.47E-02
pdx1 AK020261 0.60** 0.37** 0.70* 0.62** 1.11 1.08 1.20 0.92 4.14E-02
plec1 BM210485 1.31 0.49* 1.25 3.10** 0.53 1.38 1.04 2.87** 2.42E-02
plec1 BM232239 1.20 0.77 1.35 2.46** 3.23** 4.56** 2.82** 0.59* 2.09E-03
slc2a2 NM_031197 0.84* 0.43** 0.94 0.76** 0.74** 1.00 1.19* 0.91 2.91E-02
sprr1b NM_009265 1.14 1.13 1.10 0.76 0.24** 0.33** 0.67 0.27** 1.27E-02
tgm2 BC016492 1.21 0.74 8.27** 2.63** 0.83 1.89* 2.02** 4.55** 1.54E-03
tgm2 AW321975 1.15 1.47* 3.90** 3.73** 1.09 0.79 1.89** 1.03 1.54E-02
tgm2 BB550124 1.37* 1.36* 3.44** 2.75** 1.26 0.70* 1.91** 1.04 1.58E-02
tgm2 BB041811 1.31* 1.52** 3.05** 3.22** 1.01 0.65** 2.30** 1.22 2.44E-02
Cell Adhesion           
itga7 NM_008398 0.85 0.86 1.40* 2.86** 0.50* 1.67* 0.76 2.48** 2.14E-02
itga9 NM_133721 1.16 1.81* 1.14 1.15 0.82 1.45 1.12 2.11** 3.56E-02
itgb2 NM_008404 1.27 1.00 2.18** 3.99** 1.27 2.81** 0.65 4.16** 8.45E-03
itgb3 AV352983 0.83 0.88 1.30* 0.76* 1.12 1.54** 1.94** 2.33** 4.47E-03
itgb6 NM_021359 0.96 0.97 0.95 1.04 1.11 2.22** 1.33** 1.55** 3.45E-02
kl BQ175355 0.81 0.35** 0.92 0.86 1.04 1.09 0.87 0.89 2.13E-02
Immune Response          
h2-aa AV086906 3.97* 1.76 0.65 4.15* 0.27* 15.37** 0.48 0.92 6.05E-03
h2-d1 M34962 2.81 2.55* 1.40 5.07** 0.28* 39.62** 0.53 1.31 2.31E-03
h2-l M86502 2.32 1.79 1.83 6.04* 0.24 65.12** 0.8 1.04 5.14E-03
h2-l M69068 2.71 1.98 1.72 6.72** 0.32 48.04** 0.64 0.91 4.38E-02
il1r1 NM_008362 0.53** 0.41** 1.56* 0.62* 0.57** 1.29 1.02 1.33 5.95E-03
il6ra X53802 0.35** 0.45* 0.87 0.42** 1.40 0.77 1.06 0.70 4.70E-03
Angiogenesis           
cst7 NM_009977 0.92 0.90 1.22* 1.10 1.04 1.99** 0.95 1.45** 1.79E-02
pgf NM_008827 0.50** 0.39** 1.03 0.43** 1.03 2.29** 2.24** 6.64** 2.52E-02
vegfa NM_009505 0.83* 0.52** 0.99 0.87 1.19 2.00** 1.16 0.73* 4.27E-02
vegfa U50279 1.16 0.32** 1.12 0.65 0.86 1.79* 1.16 1.02 4.07E-02
vegfb U48800 1.34 1.21 2.29** 2.08** 0.57* 1.72* 0.88 1.33 2.16E-02
vegfc BB089170 1.18 0.69** 0.60** 1.72** 0.76* 0.40** 0.81 0.77* 2.21E-02
vegfc AW228853 1.25 0.70 0.80 3.87** 0.38** 0.51 0.79 1.82 3.87E-02
Extracellular Matrix          
klk1 BC010754 0.74 1.44 1.12 1.74 1.95 11.58** 20.38** 244.79** 1.13E-04
klk1 BC010754 1.31 1.36 1.01 1.93 2.72* 16.74** 13.93** 255.71** 4.94E-05
klk21 AB039276 0.63** 0.87 1.24 1.12 1.11 3.36** 4.16** 17.78** 4.06E-07
klk24 NM_010643 0.60* 0.81 1.24 1.15 1.64* 4.99** 12.91** 18.13** 3.33E-06
klk27 NM_020268 0.78 1.03 1.15 1.1 1.55 12.63** 45.42** 128.74** 5.94E-08
klk9 M17962 0.86 1.16 1.18 0.99 1.67 5.97** 9.03** 45.34** 1.11E-04
pgf NM_008827 0.50** 0.39** 1.03 0.43** 1.03 2.29** 2.24** 6.64** 3.14E-02
thbs2 NM_011581 0.98 0.95 1.2 1.00 1.14 1.44** 1.90** 3.92** 2.56E-07
thbs2 BB233297 0.87 1.17 0.83 1.21 2.05** 2.86** 4.37** 3.14** 1.17E-03
thbs2 NM_011581 0.99 0.94 0.99 1.05 2.23** 2.60** 5.86** 3.40** 4.14E-04
  1. Selected MYC-responsive genes relating to differentiation, angiogenesis and cellular adhesion. 'MYC-response p-value' is the p-value identified for the highest-order interaction of the MYC activation variable and represents the significance of this term within the selected model. Flags represent contrast p-values comparing 4OHT-treated and vehicle-treated samples at specific time points ('*', p ≤ 0.05; '**' p ≤ 0.01). Cells are colour-coded based on a detected fold-change greater than 1.5-fold (red, up-regulated; blue, down-regulated).