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Table 3 Differentiation, angiogenesis, and cellular adhesion genes responsive to MYC-ERTAM activation

From: Deciphering c-MYC-regulated genes in two distinct tissues

  

Pancreatic β-Cells

Suprabasal Keratinocytes

 

Gene Symbol

RefSeq

4 Hours

8 Hours

16 Hours

32 Hours

4 Hours

8 Hours

16 Hours

32 Hours

Myc-response p-value

Differentiation

          

adamts1

D67076

0.56

0.72

2.12*

1.10

1.42

1.33

3.29**

3.42**

2.89E-02

creg1

BC027426

2.08**

2.12**

1.60**

2.16**

0.69*

0.85

0.98

0.92

3.68E-02

csta

C89521

1.12

1.13

1.04

0.88

0.49**

1.04

0.34**

0.52**

1.28E-02

eg666231

C81193

1.26*

1.85**

2.40**

1.98**

0.82*

2.76**

1.19

2.29**

1.94E-02

gck

L38990

0.59*

0.14**

2.46**

0.81

1.14

1.41

1.27

1.29

2.31E-03

ins1

NM_008386

0.18*

0.42

9.94**

10.18**

1.55

1.14

1.46

1.26

1.80E-03

ins2

NM_008387

0.17*

0.36

8.70**

12.66**

0.57

1.36

1.00

0.77

1.03E-03

ivl

AV009441

0.99

1.24

1.06

1.03

0.35**

0.59**

0.22**

0.82

4.32E-02

krt1

NM_008473

1.49*

0.99

1.17

1.02

0.48**

4.02**

0.70*

0.86

4.05E-02

krt14

BC011074

1.26

1.43*

1.16

0.73*

0.89

2.02**

0.96

0.98

1.93E-02

krt14

BC011074

1.12

1.00

1.16

0.98

0.91

2.17**

0.89

1.04

2.87E-02

mnx1

NM_019944

0.57*

0.40**

0.88

1.40

0.88

1.03

1.06

0.96

1.07E-02

nkx2-2

NM_010919

0.65

0.66*

1.55

0.43**

0.91

0.76

0.97

0.65*

2.22E-02

nkx6-1

AF357883

0.53*

0.32**

2.29**

1.13

0.91

0.94

1.09

0.98

4.29E-02

odc1

S64539

1.72**

2.29**

1.83**

1.82**

1.11

1.62**

0.99

1.81**

2.43E-02

pcnt

NM_008787

2.70**

3.79**

5.22**

4.18**

1.14

1.89**

1.1

1.82**

1.37E-02

pcsk2

BB357975

2.24**

0.56*

0.69*

1.08

1.24

1.12

1.04

0.83

1.33E-02

pcsk2

AI839700

0.98

0.48**

0.71**

0.93

1.03

1.08

0.89

0.89

3.31E-02

pcsk2

NM_008792

0.42**

0.39**

1.74**

2.59**

0.94

1.01

1.10

0.96

4.15E-02

pdx1

AK020261

0.74*

0.20**

0.71*

0.47**

1.96**

1.11

1.30

0.95

3.47E-02

pdx1

AK020261

0.60**

0.37**

0.70*

0.62**

1.11

1.08

1.20

0.92

4.14E-02

plec1

BM210485

1.31

0.49*

1.25

3.10**

0.53

1.38

1.04

2.87**

2.42E-02

plec1

BM232239

1.20

0.77

1.35

2.46**

3.23**

4.56**

2.82**

0.59*

2.09E-03

slc2a2

NM_031197

0.84*

0.43**

0.94

0.76**

0.74**

1.00

1.19*

0.91

2.91E-02

sprr1b

NM_009265

1.14

1.13

1.10

0.76

0.24**

0.33**

0.67

0.27**

1.27E-02

tgm2

BC016492

1.21

0.74

8.27**

2.63**

0.83

1.89*

2.02**

4.55**

1.54E-03

tgm2

AW321975

1.15

1.47*

3.90**

3.73**

1.09

0.79

1.89**

1.03

1.54E-02

tgm2

BB550124

1.37*

1.36*

3.44**

2.75**

1.26

0.70*

1.91**

1.04

1.58E-02

tgm2

BB041811

1.31*

1.52**

3.05**

3.22**

1.01

0.65**

2.30**

1.22

2.44E-02

Cell Adhesion

          

itga7

NM_008398

0.85

0.86

1.40*

2.86**

0.50*

1.67*

0.76

2.48**

2.14E-02

itga9

NM_133721

1.16

1.81*

1.14

1.15

0.82

1.45

1.12

2.11**

3.56E-02

itgb2

NM_008404

1.27

1.00

2.18**

3.99**

1.27

2.81**

0.65

4.16**

8.45E-03

itgb3

AV352983

0.83

0.88

1.30*

0.76*

1.12

1.54**

1.94**

2.33**

4.47E-03

itgb6

NM_021359

0.96

0.97

0.95

1.04

1.11

2.22**

1.33**

1.55**

3.45E-02

kl

BQ175355

0.81

0.35**

0.92

0.86

1.04

1.09

0.87

0.89

2.13E-02

Immune Response

         

h2-aa

AV086906

3.97*

1.76

0.65

4.15*

0.27*

15.37**

0.48

0.92

6.05E-03

h2-d1

M34962

2.81

2.55*

1.40

5.07**

0.28*

39.62**

0.53

1.31

2.31E-03

h2-l

M86502

2.32

1.79

1.83

6.04*

0.24

65.12**

0.8

1.04

5.14E-03

h2-l

M69068

2.71

1.98

1.72

6.72**

0.32

48.04**

0.64

0.91

4.38E-02

il1r1

NM_008362

0.53**

0.41**

1.56*

0.62*

0.57**

1.29

1.02

1.33

5.95E-03

il6ra

X53802

0.35**

0.45*

0.87

0.42**

1.40

0.77

1.06

0.70

4.70E-03

Angiogenesis

          

cst7

NM_009977

0.92

0.90

1.22*

1.10

1.04

1.99**

0.95

1.45**

1.79E-02

pgf

NM_008827

0.50**

0.39**

1.03

0.43**

1.03

2.29**

2.24**

6.64**

2.52E-02

vegfa

NM_009505

0.83*

0.52**

0.99

0.87

1.19

2.00**

1.16

0.73*

4.27E-02

vegfa

U50279

1.16

0.32**

1.12

0.65

0.86

1.79*

1.16

1.02

4.07E-02

vegfb

U48800

1.34

1.21

2.29**

2.08**

0.57*

1.72*

0.88

1.33

2.16E-02

vegfc

BB089170

1.18

0.69**

0.60**

1.72**

0.76*

0.40**

0.81

0.77*

2.21E-02

vegfc

AW228853

1.25

0.70

0.80

3.87**

0.38**

0.51

0.79

1.82

3.87E-02

Extracellular Matrix

         

klk1

BC010754

0.74

1.44

1.12

1.74

1.95

11.58**

20.38**

244.79**

1.13E-04

klk1

BC010754

1.31

1.36

1.01

1.93

2.72*

16.74**

13.93**

255.71**

4.94E-05

klk21

AB039276

0.63**

0.87

1.24

1.12

1.11

3.36**

4.16**

17.78**

4.06E-07

klk24

NM_010643

0.60*

0.81

1.24

1.15

1.64*

4.99**

12.91**

18.13**

3.33E-06

klk27

NM_020268

0.78

1.03

1.15

1.1

1.55

12.63**

45.42**

128.74**

5.94E-08

klk9

M17962

0.86

1.16

1.18

0.99

1.67

5.97**

9.03**

45.34**

1.11E-04

pgf

NM_008827

0.50**

0.39**

1.03

0.43**

1.03

2.29**

2.24**

6.64**

3.14E-02

thbs2

NM_011581

0.98

0.95

1.2

1.00

1.14

1.44**

1.90**

3.92**

2.56E-07

thbs2

BB233297

0.87

1.17

0.83

1.21

2.05**

2.86**

4.37**

3.14**

1.17E-03

thbs2

NM_011581

0.99

0.94

0.99

1.05

2.23**

2.60**

5.86**

3.40**

4.14E-04

  1. Selected MYC-responsive genes relating to differentiation, angiogenesis and cellular adhesion. 'MYC-response p-value' is the p-value identified for the highest-order interaction of the MYC activation variable and represents the significance of this term within the selected model. Flags represent contrast p-values comparing 4OHT-treated and vehicle-treated samples at specific time points ('*', p ≤ 0.05; '**' p ≤ 0.01). Cells are colour-coded based on a detected fold-change greater than 1.5-fold (red, up-regulated; blue, down-regulated).
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