Figure 6

Structural analysis of Cp CDPK4. (A) Overall view of Cp CDPK4 [PDB: 3HKO] with the zinc finger and β-mesh insert highlighted in lime. (B) Zn-finger of Cp CDPK4 is shown with the residues involved in zinc binding noted. (C) Overlay of aligned views of Cp CDPK4 with the C-terminus of the KD and entire CAD of Tg CDPK1 (for visual clarity the N-terminal portion of the KD is not shown) in grey [PDB: 3KU2]. (D) An overall structural comparison of Cp CDPK4 (teal/lime) and PKC-ι (salmon/magenta) [PDB:3AX8] with the C-terminal tail (from K531) highlighted in magenta and a circle indicating its overlap with Cp CDPK4. (E) An overall structural comparison of Cp CDPK4 (teal/lime) and human CLK1 (pale yellow) [PDB:1Z57]. (F) An overall structural comparison of Cp CDPK4 (teal/lime) and human SRPK (beige) [PDB:1WBP].