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Table 3 Top three network functions obtained by IPA for the differentially expressed genes of each comparison 3 days after scale removal.

From: Skin healing and scale regeneration in fed and unfed sea bream, Sparus auratus

Group

Top Network Functions

Score

Focus Molecules

Control v. Without scales (WS)

 

Small Molecule Biochemistry, Genetic Disorder, Metabolic Disease

34

17

 

Cell Morphology, Cancer, Cell Cycle

29

15

 

Cell-To-Cell Signaling and Interaction, Cellular Movement, Tissue Development

26

13

Control v. Starved (ST)

 

Lipid Metabolism, Nucleic Acid Metabolism, Small Molecule Biochemistry

46

22

 

Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function

31

16

 

Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking

30

16

Control v. Starved without scales (STWS)

 

Cancer, Gastrointestinal Disease, Tumor Morphology

39

20

 

Cancer, Reproductive System Disease, Genetic Disorder

30

16

 

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

26

14

Starved (ST) v. Starved without scales (STWS)

 

Cancer, Gastrointestinal Disease, DNA Replication, Recombination, and Repair

46

27

 

Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism

39

24

 

Endocrine System Development and Function, Lipid Metabolism, Skeletal and Muscular System Development and Function

36

23

  1. Score and number of molecules in each network are given.