Central role of transcription factor HNF4A in the region-specific response of cerebellum to hypoxia. (A). Network diagram showing the interactions between HNF4A and its numerous target genes that were up-regulated by hypoxia at least 1.2-fold in the cerebellum, but not in the hippocampus. The orange lines indicate interactions between molecules. (B). Baseline expression pattern of HNF4A at the cellular level in the cerebellum of 8-week old male C57BL/6J mice using in situ hybridization(ISH) (Image ID 1746, Specimen ID 2397, Position 1875 from Allen Mouse Brain Atlas, Allen Institute for Brain Science, Seattle, WA, http://mouse.brain-map.org, accessed in April 2009). The left panel is the high power view of HNF4A expression in cerebellum cortex (the framed area in the right panel). The expression level is color coded. The right panel is the original Allen Mouse Brain Atlas image of the whole cerebellum (coronal section).