Table 2 Functional categories of addiction susceptibility SNPs

SNPs Introducing Non-Synonymous Mutations

26

23

0.001*

SNPs Introducing Synonymous Mutations

25

21

0.001*

SNPs Introducing Stop Codon Gain

0

0

1.00

SNPs Introducing Stop Codon Lost

0

0

1.00

SNPs Introducing ORF Frame Shift

0

0

1.00

SNPs Introducing Altered Splicing Junction

1

1

0.92

SNPs Introducing Altered TF Binding Sites

4

4

0.83

SNPs Introducing Altered miRNA Targets

2

2

0.28

SNPs Correlated With Differentially Gene Expression

24

2

0.42

SNPs Under Positive Selection

34

19

0.99

SNPs Under Negative Selection

31

26

0.05*

Functional Addiction Susceptibility SNPs

124

70

0.63

All SNPs in The Positive Haplotypes

1907

843

1.00