Skip to main content

Table 2 Functional categories of addiction susceptibility SNPs

From: Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction

Functional Categories Vulnerable SNP Number Haplotype
Number
Monte Carlo
p-values
SNPs Introducing Non-Synonymous Mutations 26 23 0.001*
SNPs Introducing Synonymous Mutations 25 21 0.001*
SNPs Introducing Stop Codon Gain 0 0 1.00
SNPs Introducing Stop Codon Lost 0 0 1.00
SNPs Introducing ORF Frame Shift 0 0 1.00
SNPs Introducing Altered Splicing Junction 1 1 0.92
SNPs Introducing Altered TF Binding Sites 4 4 0.83
SNPs Introducing Altered miRNA Targets 2 2 0.28
SNPs Correlated With Differentially Gene Expression 24 2 0.42
SNPs Under Positive Selection 34 19 0.99
SNPs Under Negative Selection 31 26 0.05*
Functional Addiction Susceptibility SNPs 124 70 0.63
All SNPs in The Positive Haplotypes 1907 843 1.00
\