Table 4 Top 50 genes significantly differentially regulated in cord based on fold difference (t-test).
Gene Symbol | 2Way ANOVA P value | Fold Change in cord, Welch t-test | Regulation in LBW | Fold change skeletal tissue, Welch t-test | Regulation in LBW | Fold change in liver, | Regulation in LBW | Gene name |
|---|---|---|---|---|---|---|---|---|
ATP5F1 | 0.003504217 | 29.998667 | down | 1.850386 | down | 1.153583 | down | Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 (ATP5F1), nuclear gene encoding mitochondrial protein, mRNA [NM_001688] |
EHHADH | 3.25E-05 | 29.713446 | down | 1.004504 | up | 1.027032 | down | Homo sapiens enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (EHHADH), mRNA [NM_001966] |
CNPY2 | 6.12E-05 | 24.275322 | down | 2.033511 | down | 1.345912 | down | Homo sapiens transmembrane protein 4 (TMEM4), mRNA [NM_014255] |
IMMP1L | 5.31E-04 | 21.21959 | down | 1.067236 | down | 1.052987 | up | Homo sapiens IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) (IMMP1L), mRNA [NM_144981] |
GNL2 | 0.008845676 | 19.523186 | down | 1.389994 | down | 1.352022 | up | Homo sapiens guanine nucleotide binding protein-like 2 (nucleolar) (GNL2), mRNA [NM_013285] |
HRSP12 | 0.010644738 | 19.35189 | down | 1.121147 | up | 1.013192 | up | Homo sapiens heat-responsive protein 12 (HRSP12), mRNA [NM_005836] |
CN643639 | 2.57E-05 | 19.177528 | down | 1.710693 | down | 1.132373 | up | ILLUMIGEN_MCQ_8235 Katze_MMBR Macaca mulatta cDNA clone IBIUW:3333 5' similar to Bases 1 to 682 highly similar to human Unigene Hs.513885, mRNA sequence [CN643639] |
PASK | 0.03426426 | 19.17474 | up | 5.977056 | up | 2.995584 | up | Homo sapiens PAS domain containing serine/threonine kinase (PASK), mRNA [NM_015148] |
NDUFC1 | 1.93E-04 | 18.786453 | down | 1.418954 | down | 1.095977 | up | Homo sapiens NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6 kDa (NDUFC1), mRNA [NM_002494] |
BNIP3L | 3.67E-05 | 18.46857 | down | 2.523903 | down | 1.123252 | down | Homo sapiens BCL2/adenovirus E1B 19 kDa interacting protein 3-like (BNIP3L), mRNA [NM_004331] |
GALE | 0.004030123 | 18.304993 | down | 1.591229 | up | 1.378757 | down | Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 1, mRNA [NM_000403] |
XM_371837 | 2.06E-06 | 18.251152 | down | 1.76245 | down | 1.15429 | down | PREDICTED: Homo sapiens similar to oxidoreductase UCPA (LOC389416), mRNA [XM_371837] |
OSTCL | 9.90E-05 | 17.57389 | down | 1.173702 | down | 1.075778 | down | Homo sapiens similar to RIKEN cDNA 2310008M10 (LOC202459), mRNA [NM_145303] |
WDR75 | 7.83E-05 | 17.02899 | down | 2.353145 | down | 1.037028 | down | Homo sapiens WD repeat domain 75 (WDR75), mRNA [NM_032168] |
SMPDL3A | 1.25E-05 | 16.127317 | down | 1.290077 | down | 1.780315 | down | Homo sapiens sphingomyelin phosphodiesterase, acid-like 3A (SMPDL3A), mRNA [NM_006714] |
LIN7C | 6.29E-04 | 15.929515 | down | 1.429568 | down | 1.006664 | down | Homo sapiens lin-7 homolog C (C. elegans) (LIN7C), mRNA [NM_018362] |
COX7B | 8.03E-06 | 15.9135065 | down | 1.283232 | down | 1.138854 | up | Homo sapiens cytochrome c oxidase subunit VIIb (COX7B), nuclear gene encoding mitochondrial protein, mRNA [NM_001866] |
MRPL1 | 1.35E-06 | 15.901582 | down | 1.776047 | down | 1.05264 | up | Homo sapiens mitochondrial ribosomal protein L1 (MRPL1), nuclear gene encoding mitochondrial protein, mRNA [NM_020236] |
NPM3 | 3.58E-04 | 15.357531 | down | 1.39378 | down | 1.314134 | up | Homo sapiens nucleophosmin/nucleoplasmin, 3 (NPM3), mRNA [NM_006993] |
RNF126 | 4.43E-04 | 15.14725 | down | 1.165075 | down | 1.084156 | down | Homo sapiens ring finger protein 126 (RNF126), transcript variant 2, mRNA [NM_194460] |
ATG4C | 1.86E-06 | 14.422242 | down | 1.01449 | down | 1.571663 | down | Homo sapiens ATG4 autophagy related 4 homolog C (S. cerevisiae) (ATG4C), transcript variant 7, mRNA [NM_032852] |
ACMSD | 2.00E-04 | 14.3137 | down | 1.121731 | up | 1.098467 | down | Homo sapiens aminocarboxymuconate semialdehyde decarboxylase (ACMSD), mRNA [NM_138326] |
WASF3 | 0.0026955 | 14.211387 | down | 1.134297 | down | 1.574282 | up | Homo sapiens WAS protein family, member 3 (WASF3), mRNA [NM_006646] |
F13B | 1.26E-05 | 13.94526 | down | 1.052562 | down | 1.02993 | down | Homo sapiens coagulation factor XIII, B polypeptide (F13B), mRNA [NM_001994] |
HNRNPA1L2 | 0.007305239 | 13.879195 | down | 1.288451 | up | 1.062584 | down | Homo sapiens heterogeneous nuclear ribonucleoprotein A1-like (LOC144983), transcript variant 1, mRNA [NM_001011724] |
XR_011737 | 0.001940294 | 13.592515 | down | 1.736661 | down | 1.168041 | up | PREDICTED: Macaca mulatta similar to transcription factor B2, mitochondrial (LOC710669), mRNA [XR_011737] |
CP | 1.42E-04 | 13.285389 | down | 1.122256 | down | 1.274657 | down | Homo sapiens ceruloplasmin (ferroxidase) (CP), mRNA [NM_000096] |
TOLLIP | 1.59E-04 | 12.683504 | down | 1.156986 | down | 1.00844 | down | Homo sapiens toll interacting protein (TOLLIP), mRNA [NM_019009] |
DARS | 3.99E-05 | 12.632657 | down | 3.152794 | down | 1.10567 | down | Homo sapiens aspartyl-tRNA synthetase (DARS), mRNA [NM_001349] |
CKLF | 4.24E-04 | 12.476327 | down | 1.130294 | down | 1.064736 | down | Homo sapiens chemokine-like factor (CKLF), transcript variant 1, mRNA [NM_016951] |
STT3B | 1.13E-04 | 12.457355 | down | 2.027118 | down | 1.030927 | down | Homo sapiens STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) (STT3B), mRNA [NM_178862] |
TXNDC11 | 4.40E-05 | 12.377014 | down | 1.525444 | down | 1.011564 | down | Homo sapiens thioredoxin domain containing 11 (TXNDC11), mRNA [NM_015914] |
CR603105 | 9.80E-04 | 12.209639 | down | 1.284419 | down | 1.155491 | down | full-length cDNA clone CS0DF006YN22 of Fetal brain of Homo sapiens (human) [CR603105] |
XR_010672 | 5.09E-05 | 11.634537 | down | 1.602301 | down | 1.059423 | up | PREDICTED: Macaca mulatta similar to Molybdenum cofactor synthesis protein 2 large subunit (Molybdopterin synthase large subunit) (MPT synthase large subunit) (MOCS2B) (MOCO1-B) (LOC703049), mRNA [XR_010672] |
GDE1 | 0.03917646 | 11.536806 | down | 1.190901 | up | 1.20255 | up | Homo sapiens membrane interacting protein of RGS16 (MIR16), mRNA [NM_016641] |
CFHR2 | 2.07E-04 | 11.37657 | down | 1.208862 | down | 1.032327 | down | Homo sapiens complement factor H-related 2 (CFHR2), mRNA [NM_005666] |
RPL30 | 0.03067462 | 11.374878 | down | 1.173423 | up | 1.096937 | up | Homo sapiens ribosomal protein L30 (RPL30), mRNA [NM_000989] |
XM_495885 | 0.002429009 | 11.322625 | down | 1.165255 | down | 1.156577 | down | PREDICTED: Homo sapiens similar to ribosomal protein S12 (LOC440055), mRNA [XM_495885] |
NDUFB1 | 2.13E-04 | 11.293429 | down | 1.404433 | down | 1.277028 | up | Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7 kDa (NDUFB1), mRNA [NM_004545] |
NM_032807 | 2.89E-04 | 11.240869 | down | 1.075345 | down | 1.014724 | down | Homo sapiens F-box protein, helicase, 18 (FBXO18), transcript variant 1, mRNA. [NM_032807] |
CSGALNACT 2 | 1.34E-05 | 11.216295 | down | 1.714551 | down | 1.080183 | down | Homo sapiens chondroitin sulfate GalNAcT-2 (GALNACT-2), mRNA [NM_018590] |
NM_022333 | 0.002598488 | 10.94874 | down | 1.130622 | up | 1.014866 | down | Homo sapiens TIA1 cytotoxic granule-associated RNA binding protein-like 1 (TIAL1), ranscript variant 2, mRNA [NM_022333] |
NM_032807 | 0.001172931 | 10.342792 | down | 1.522541 | down | 1.139832 | down | Homo sapiens F-box protein, helicase, 18 (FBXO18), transcript variant 1, mRNA. [NM_032807] |
AAMP | 2.62E-05 | 10.171815 | down | 1.560637 | down | 1.085371 | down | Homo sapiens angio-associated, migratory cell protein (AAMP), mRNA [NM_001087] |
ESF1 | 1.02E-07 | 9.745275 | down | 1.620818 | down | 1.008674 | down | Homo sapiens ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) (ESF1), mRNA [NM_016649] |
DOCK7 | 0.01799708 | 9.74066 | down | 1.174452 | up | 1.171709 | up | Homo sapiens dedicator of cytokinesis 7 (DOCK7), mRNA [NM_033407] |
DDX3Y | 4.78E-06 | 9.687978 | down | 1.356089 | down | 1.134329 | down | Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked (DDX3Y), mRNA [NM_004660] |
XIAP | 3.65E-05 | 9.587557 | down | 1.882389 | down | 1.280735 | up | Homo sapiens baculoviral IAP repeat-containing 4 (BIRC4), mRNA [NM_001167] |
TRPC4AP | 9.51E-05 | 9.4549885 | down | 1.340843 | down | 1.07043 | up | Homo sapiens transient receptor potential cation channel, subfamily C, member 4 associated protein (TRPC4AP), transcript variant 1, mRNA [NM_015638] |
ADK | 1.63E-04 | 9.386349 | down | 5.639505 | down | 1.368648 | down | Homo sapiens adenosine kinase (ADK), transcript variant ADK-short, mRNA [NM_001123] |
NM_0010022 92 | 3.92E-04 | 9.258961 | down | 1.016391 | up | 1.220083 | down | Homo sapiens chromosome 1 open reading frame 139 (C1orf139), transcript variant 2, mRNA. [NM_001002292] |