Sequence alignment of 3' and 5' ends of the HSP90 gene and contiguous intergenic regions. Coding regions have been translated to amino acid sequences to highlight the position of synonymous (open circles) and non-synonymous (filled circles) substitutions. Note a single non synonymous substitution occurred at amino acid position -28. The lengths of 3'/5' UTRs (blue) and intergenic regions (red) were inferred from comparison of genomic and cDNA sequences. IG1-6 refer to genomic sequence classes derived from PCR and cloning of the intergenic region.