Gene ontology and interacting gene analysis results. A. Gene ontology analysis results of up- and down-regulated proteins in EAM rat heart tissue using the PANTHER database . B. Interacting gene analysis results of dysregulated proteins using the STRING database. Nodes with red colors indicate the up-regulated proteins in EAM rat heart tissues compared with those of control rat heart tissues, while the blue colors represent the down-regulated proteins. The size of each node represents the amount of structural information associated with each protein. Confidently associated proteins have pre-calculated links between the two enzymes or proteins in the same metabolic map in the KEGG database, and the width of the lines correlates with the confidence score [13, 14].