Table 1 Allocation of dysregulated proteins in EAM rats according to their biological function
GO Biological process | Name of proteins | Accession No. | Spot No. | up-regulated (↑) down-regulated (↓) |
|---|---|---|---|---|
Apoptosis | Txn | IPI00231368.5 | 1086 | ↑ |
Cell communication | Txn | IPI00231368.5 | 1086 | ↑ |
|  | Anxa3 | IPI00207390.9 | 638 | ↑ |
|  | Clic1 | IPI00421995.1 | 713 | ↑ |
|  | Arhgdib | IPI00358463.1 | 837 | ↑ |
|  | Cabp1 | IPI00558996.2 | 136, 148 | ↑ |
|  | Trim72 | IPI00361208.4 | 309 | ↓ |
Cell cycle | Txn | IPI00231368.5 | 1086 | ↑ |
|  | Tuba4a | IPI00362927.1 | 243 | ↑ |
|  | Tuba1a | IPI00189795.1 | 243 | ↑ |
|  | Cabp1 | IPI00558996.2 | 136, 148 | ↑ |
|  | Tua1b | IPI00339167.4 | 243 | ↑ |
|  | Trim72 | IPI00361208.4 | 309 | ↓ |
Cellular component organization | Tpm4 | IPI00210941.1 | 684 | ↑ |
|  | Tuba4a | IPI00362927.1 | 243 | ↑ |
|  | Tpm3 | IPI00191354.2 | 684 | ↑ |
|  | Tpm2 | IPI00187731.4 | 684, 685 | ↑ |
|  | Tuba1a | IPI00189795.1 | 243 | ↑ |
|  | Capg | IPI00464670.1 | 477 | ↑ |
|  | Tuba1b | IPI00339167.4 | 243 | ↑ |
|  | Tpm1 | IPI00197888.2 | 614 | ↓ |
Cellular process | Tpm4 | IPI00210941.1 | 684 | ↑ |
|  | Txn | IPI00231368.5 | 1086 | ↑ |
|  | Anxa3 | IPI00207390.9 | 638 | ↑ |
|  | Tuba4a | IPI00362927.1 | 243 | ↑ |
|  | Tpm3 | IPI00191354.2 | 684 | ↑ |
|  | Tpm2 | IPI00187731.4 | 684, 685 | ↑ |
|  | Clic1 | IPI00421995.1 | 713 | ↑ |
|  | Tuba1a | IPI00189795.1 | 243 | ↑ |
|  | Capg | IPI00464670.1 | 477 | ↑ |
|  | Arhgdib | IPI00358463.1 | 837 | ↑ |
|  | Cabp1 | IPI00558996.2 | 136, 148 | ↑ |
|  | Tuba1b | IPI00339167.4 | 243 | ↑ |
|  | Trim72 | IPI00361208.4 | 309 | ↓ |
|  | Tpm1 | IPI00197888.2 | 614 | ↓ |
Developmental process | Tpm4 | IPI00210941.1 | 684 | ↑ |
|  | Tuba4a | IPI00362927.1 | 243 | ↑ |
|  | Tpm3 | IPI00191354.2 | 684 | ↑ |
|  | Tpm2 | IPI00187731.4 | 684, 685 | ↑ |
|  | Tuba1a | IPI00189795.1 | 243 | ↑ |
|  | Capg | IPI00464670.1 | 477 | ↑ |
|  | Tuba1b | IPI00339167.4 | 243 | ↑ |
|  | Ddah2 | IPI00215294.1 | 691 | ↑ |
|  | Trim72 | IPI00361208.4 | 309 | ↓ |
|  | Myl2 | IPI00214000.4 | 968 | ↓ |
|  | Tpm1 | IPI00197888.2 | 614 | ↓ |
Generation of precursor metabolites and energy | Txn | IPI00231368.5 | 1086 | ↑ |
|  | Atp5b | IPI00551812.1 | 318 | ↓ |
|  | Atp5d | IPI00198620.1 | 1036 | ↓ |
|  | Ldhb | IPI00231783.5 | 1112 | ↓ |
|  | Ndufs1 | IPI00358033.1 | 89 | ↓ |
|  | Ivd | IPI00193716.1 | 464 | ↓ |
|  | Mdh1 | IPI00198717.8 | 580, 599, 1107 | ↓ |
|  | Uqcrc1 | IPI00471577.1 | 356 | ↓ |
|  | Idh3a | IPI00198720.1 | 509 | ↓ |
Immune system process | Txn | IPI00231368.5 | 1086 | ↑ |
|  | GRP94 | IPI00365985.5 | 53 | ↑ |
|  | GRP78 | IPI00206624.1 | 107 | ↑ |
|  | Crp | IPI00188225.1 | 763 | ↑ |
|  | Clic1 | IPI00421995.1 | 713 | ↑ |
|  | Hspb1 | IPI00201586.1 | 814 | ↑ |
|  | Kng1 | IPI00515829.1 | 136, 143, 148 | ↑ |
|  | Hp | IPI00382202.2 | 364, 568, 578, 604, 808 | ↑ |
|  | Hspb2 | IPI00213296.1 | 930 | ↓ |
|  | Hspa8 | IPI00208205.1 | 1108 | ↓ |
Metabolic process | Serpina1 | IPI00324019.1 | 859 | ↑ |
|  | Nme1 | IPI00194404.5 | 994 | ↑ |
|  | Atp5b | IPI00551812.1 | 318 | ↓ |
|  | Hibadh | IPI00202658.1 | 696 | ↓ |
|  | Atp5d | IPI00198620.1 | 1036 | ↓ |
|  | Ldhb | IPI00231783.5 | 1112 | ↓ |
|  | Ivd | IPI00193716.1 | 464 | ↓ |
|  | Mdh1 | IPI00198717.8 | 580, 599, 1107 | ↓ |
|  | Uqcrc1 | IPI00471577.1 | 356 | ↓ |
|  | Bckdhb | IPI00201636.3 | 536 | ↓ |
|  | Hspb2 | IPI00213296.1 | 930 | ↓ |
|  | Trim72 | IPI00361208.4 | 309 | ↓ |
|  | Idh3a | IPI00198720.1 | 509 | ↓ |
|  | Dlst | IPI00551702.2 | 295, 384 | ↓ |
|  | Ckb | IPI00470288.4 | 373 | ↓ |
|  | Pcca | IPI00765682.2 | 105 | ↓ |
|  | Hsdl2 | IPI00367240.3 | 112 | ↓ |
|  | Dlat | IPI00231714.3 | 167, 173, 183 | ↓ |
|  | Aldh2 | IPI00197770.1 | 295, 297 | ↓ |
|  | Bckdha | IPI00365663.1 | 383 | ↓ |
|  | Pdhb | IPI00194324.2 | 1108 | ↓ |
|  | Hspa8 | IPI00208205.1 | 126 | ↓ |
|  | Hspd1 | IPI00339148.2 | 212 | ↓ |
Regulation of biological process | Kng1 | IPI00515829.1 | 136, 143, 148 | ↑ |
Reproduction | Hp | IPI00382202.2 | 364, 568, 578, 604, 808 | ↑ |
|  | Trim72 | IPI00361208.4 | 309 | ↓ |
Response to stimulus | Txn | IPI00231368.5 | 1086 | ↑ |
|  | GRP94 | IPI00365985.5 | 53 | ↑ |
|  | GRP78 | IPI00206624.1 | 107 | ↑ |
|  | Crp | IPI00188225.1 | 763 | ↑ |
|  | Clic1 | IPI00421995.1 | 713 | ↑ |
|  | Hspb1 | IPI00201586.1 | 814 | ↑ |
|  | Kng1 | IPI00515829.1 | 136, 143, 148 | ↑ |
|  | Hp | IPI00382202.2 | 364, 568, 578, 604, 808 | ↑ |
|  | Hspb2 | IPI00213296.1 | 930 | ↓ |
|  | Hspa8 | IPI00208205.1 | 126 | ↓ |
System process | Tpm4 | IPI00210941.1 | 684 | ↑ |
|  | Tpm3 | IPI00191354.2 | 684 | ↑ |
|  | Tpm2 | IPI00187731.4 | 684, 685 | ↑ |
|  | Apoa1 | IPI00197703.2 | 842 | ↑ |
|  | Hspb1 | IPI00201586.1 | 814 | ↑ |
|  | Kng1 | IPI00515829.1 | 136, 143, 148 | ↑ |
|  | Hp | IPI00382202.2 | 364, 568, 578, 604, 808 | ↑ |
|  | Hspb2 | IPI00213296.1 | 930 | ↓ |
|  | Trim72 | IPI00361208.4 | 309 | ↓ |
|  | Myl2 | IPI00214000.4 | 968 | ↓ |
|  | Ckb | IPI00470288.4 | 373 | ↓ |
|  | Tpm1 | IPI00197888.2 | 614 | ↓ |
|  | Hsdl2 | IPI00367240.3 | 112 | ↓ |
Transport | Hpx | IPI00195516.6 | 95, 100, 124 | ↑ |
|  | Alb | IPI00191737.6 | 143 | ↑ |
|  | Gc | IPI00194097.5 | 254 | ↑ |
|  | Anxa3 | IPI00207390.9 | 638 | ↑ |
|  | Tuba4a | IPI00362927.1 | 243 | ↑ |
|  | Clic1 | IPI00421995.1 | 713 | ↑ |
|  | Erp29 | IPI00207184.1 | 765 | ↑ |
|  | Tuba1a | IPI00189795.1 | 243 | ↑ |
|  | Apoa1 | IPI00197703.2 | 842 | ↑ |
|  | Tuba1b | IPI00339167.4 | 243 | ↑ |
|  | Atp5b | IPI00551812.1 | 318 | ↓ |
|  | Atp5d | IPI00198620.1 | 1036 | ↓ |
|  | Trim72 | IPI00361208.4 | 309 | ↓ |