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Table 2 Candidate gene targets identified in this study.

From: Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations

Gene

Name

miRNA species

BAI3

brain-specific angiogenesis inhibitor 3

miR-922; miR-548b-5p; miR-548c-5p

GK

glycerol kinase

miR-571; miR-548b-5p; miR-548c-5p

SLC23A2

solute carrier family 23 (nucleobase transporters), member 2

miR-922; miR-548b-5p; miR-548c-5p

GTDC1

glycosyltransferase-like domain containing 1

miR-516a-3p; miR-571

CNR1

cannabinoid receptor 1

miR-548b-5p; miR-548c-5p

FAM134B

family with sequence similarity 134, member B

miR-548b-5p; miR-548c-5p

HS2ST1

heparan sulfate 2-O-sulfotransferase 1

miR-548b-5p; miR-548c-5p

MYT1L

myelin transcription factor 1-like

miR-548b-5p; miR-548c-5p

NCAM1

neural cell adhesion molecule 1

miR-548b-5p; miR-548c-5p

TMEM135

transmembrane protein 135

miR-548b-5p; miR-548c-5p

ATP8A1

ATPase, class I, type 8A, member 1

miR-922

KCNAB1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

miR-922

PTPRD

protein tyrosine phosphatase, receptor type, D

miR-922

RASA1

RAS p21 protein activator 1

miR-922

REEP1

receptor accessory protein 1

miR-922

SNCA

synuclein, alpha

miR-922

A2BP1

ataxin-2-binding protein 1

miR-516a-3p

ASTN1

astrotactin 1

miR-516a-3p

  1. List of top scoring genes predicted to be regulated by the 5 significantly upregulated miRNAs (miR-922, miR-516a-3p, miR-571, miR-548b-5p, and miR-548c-5p) from the 177 mRNAs significantly downregulated in frontal cortex and cerebellum in PGRN+ compared to PGRN- FTLD-TDP patients (GEO record GDS3459).