Table 3 Top Canonical Pathways for gene-associated probes that show variable methylation within each gestational age
Variable in First trimester | p-value | genes |
|---|---|---|
Arachidonic Acid Metabolism | 6.97E-04 | CBR1, CYP2E1, GPX7, PNPLA3, PTGS1 |
Hepatic Fibrosis/Hepatic Stellate Cell Activation | 1.36E-02 | CYP2E1, ECE1, FGFR1, MYL5 |
Circadian Rhythm Signaling | 1.91E-02 | GRIN3A, VIPR2 |
Calcium Signaling | 2.69E-02 | CHRNB4, GRIA4, GRIN3A, MYL5 |
Nitrogen Metabolism | 3.54E-02 | PTPRG, VNN3 |
Variable in Second trimester | p-value | genes |
Circadian Rhythm Signaling | 3.39E-03 | GRIN3A, VIPR2, PER1 |
Glutathione Metabolism | 1.62E-02 | GPX3, GPX7, GSTO1 |
Arachidonic Acid Metabolism | 1.86E-02 | CBR1, CYP2E1, GPX3, GPX7 |
Sonic Hedgehog Signaling | 3.7E-02 | DYRK1B, HKR1 |
Metabolism of Xenobiotics by Cytochrome P450 | 4.68E-02 | ADHFE1, CYP2E1, GSTO1 |
Variable in Third trimester | p-value | genes |
Glutamate Receptor Signaling | 6.1E-03 | GRID2, GRIK2, GRIN3A, GRM6, SLC1A6 |
Valine, Leucine and Isoleucine Degradation | 1.13E-02 | ACADL, ALDH1A3, ELOVL2, IVD, OXCT1 |
β-alanine Metabolism | 2.07E-02 | ACADL, ALDH1A3, DPYS, IVD |
Butanoate Metabolism | 3.74E-02 | ALDH1A3, ELOVL2, OXCT1, PDHA2 |
Tyrosine Metabolism | 4.19E-02 | ADHFE1, ADLH1A3, ELOVL2, MGMT |