Figure 11

High resolution FISH with TR-54B-MM probe. A: (a) bone marrow prophase chromosome spread. DAPI in blue, FISH signal in green; bar - 5 μm; additionally shown a negative DAPI-banded central core of chromosomes (b) and "fuzzy" structure of whole DAPI-stained chromosomes (c). B: In each group the middle image is from atlas [41], the side (left and right) negative DAPI-banded chromosomes are from the plate. Ten chromosomes with the label are indicated by circles; chromosome X bearing the label in accordance with in silico prediction indicated by orange circle. The labels on the short chromatin loops marked with blue asterisks; label belongs to the long loops marked with red circles.