Figure 1

Circular representation of the Helicobacter bizzozeronii CIII-1 chromosome. From the outside in: the outer circle 1 shows the size in base pairs; circles 2 and 3 show the position of CDS transcribed in a clockwise and anti-clockwise direction, respectively (for color codes see below); circle 4 shows the position of insertion elements (IS and mini-IS, violet); circle 5 shows the results from Alien Hunter program from the lowest score (light pink) to the highest score (red) (threshold score value: 16.971); circle 6 shows the positions of the genomic island (brown) and prophage (orange); circle 7 shows a plot of G+C content (in a 10-kb window); circle 8 shows a plot of GC skew ([G_C]/[G+C]; in a 10-kb window). Genes in circles 2 and 3 are color-coded according to the following category: wine red, genes involved in central metabolism and respiration without orthologues in H. pylori; cyan, methyl-accepting chemotaxis proteins (MCPs); dark blue, type IV secretion system; sky blue, genes involved in acid acclimation; green, putative secreted virulence factors; pale green, glycosyltransferse gene cluster specific of H. bizzozeronii; pale grey, all other CDSs. ACC, acetophenone carboxylase; comB, Type IV secretion system; NAP, periplasmic nitrate reductase; AHD, allophanate hydrolase; GT, glycosyltransferase; NRS, nitrite reductase system; SNO, S- and N- oxidases; FDH, formate reductase system; PL, polysaccharide lyase.