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Table 1 Candidate epigenetically regulated miRNAs

From: Discovery pipeline for epigenetically deregulated miRNAs in cancer: integration of primary miRNA transcription

    Tiling array Mature miRNA fold change Reference
Name Chr Str RNA DNA meth. H3K9Ac ChIP L v P p L v 5Aza p P v 5Aza p Epi./Cancer
MIRLET7c 21 + 34.26 -0.14 3.07 54.948 * 0.986   1.505   -/[33]
MIR141 12 + 7.2 -0.46 4.31 2.928 * 2.235 * 1.110   [34]
MIR15b 3 + 11.41 -4.65 -4.02 2.071 * 0.616   0.986   -/[35]
MIR16-2 3 + 10.52 -3.6 -2.54 2.713 * 1.424 * 0.742   -/[36]
MIR423 17 + 8.91 -0.81 2.39 4.857 * 0.774   2.445 * -/[37]
MIR491 9 + 9.03 -2.08 0.83 5.352 * 1.117   1.301   -/[38]
MIR615 12 + 4.03 -3.45 5.5 1.9E+03 * 1.231   32.672 * -/-
MIR618 12 - 4.18 2.44 5.73 4.1E+02 * 1.945 * 1.385   -/[39]
MIR99a 21 + 26.52 -2.9 3.72 2.329 * 1.035   0.908   -/[40]
MIR130a 11 + -7.19 -1.92 -3.85 0.004 * 2.532 * 1.102   -/[41]
MIR135b 1 - -3.93 2.8 -7.82 0.003 * 0.337   1.828   -/[42]
MIR137 1 - -3.81 1.19 -3.41 0.016 * 2.173   5.897   [43]
MIR196b 7 - -11.26 2.07 -5.05 0.356 * 1.591 * 0.829   [21]/[44]
MIR205 1 + -26.47 2.37 -12.09 1.2E-05 * 1.1E+02 * 1.659   [13]/[15]
MIR21 17 + -21.68 13.78 -12.98 0.637 * 2.362 * 3.272 * [19]/[18]
MIR24-1 9 + -5.64 3.73 -0.27 0.057 * 1.569 * 1.231   -/[45]
MIR31 9 - -2.79 -9.75 -3.04 1.7E-06 * 1.357   0.959   -/[46]
MIR376a-2 14 + -5.98 2.96 2.59 0.020 * 4.857   2.888   -/[47]
MIR424 X - -3.94 1.95 -2.56 0.259 * 0.883   4.287 * -/[39]
MIR654 14 + -5.42 2.57 4.14 0.136 * 1.357   0.295 * -/-
  1. Table listing significantly changed miRNA genes identified in this study. Values represent relative change in LNCaP compared to PrEC. Tiling array t-statistics represent the significance of the average difference for each miRNA, with increasing values indicating higher significance level. Mature miRNA levels are given as -fold change with the associated p-value. The four miRNAs found to be significant in all our criteria are highlighted in bold type. Chr: Chromosome, Str: Strand, meth: DNA-methylation, L: LNCaP, P: PrEC, 5Aza: treatment with 5-Aza-CdR, p *: p-value < 0.05, Epi./Cancer: publication indicating epigenetic/cancer regulation.