TY - JOUR AU - Marigorta, Urko M. AU - Lao, Oscar AU - Casals, Ferran AU - Calafell, Francesc AU - Morcillo-Suárez, Carlos AU - Faria, Rui AU - Bosch, Elena AU - Serra, François AU - Bertranpetit, Jaume AU - Dopazo, Hernán AU - Navarro, Arcadi PY - 2011 DA - 2011/01/24 TI - Recent human evolution has shaped geographical differences in susceptibility to disease JO - BMC Genomics SP - 55 VL - 12 IS - 1 AB - Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a figure that keeps increasing, especially with the recent explosion of array-based Genome-Wide Association Studies. Even if the number of true associations described so far is high, many of the putative risk variants detected so far have failed to be consistently replicated and are widely considered false positives. Here, we focus on the world-wide patterns of replicability of published association studies. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-12-55 DO - 10.1186/1471-2164-12-55 ID - Marigorta2011 ER -