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Table 1 Summary of Spearman's correlation coefficients between FST and ϕ as the discordance in replicabilities for the 37 associations from the Continental Set

From: Recent human evolution has shaped geographical differences in susceptibility to disease

ASSOCIATIONS CATHEGORY POOLINGa VARIABLEb N   P value
Full Set All SNPs By Gene Average FST 33 0.496 * 0.003
    Variance FST 32 0.636 * 7 × 10 -5
   Independently Average FST 3710 0.155 * 2.58 × 10 -21
  tagSNPs By Gene Average FST 33 0.187 0.313
   Independently Average FST 538 0.16 * 2.02 × 10 -4
Conservative Setc All SNPs By Gene Average FST 26 0.666 * 0.0002
    Variance FST 24 0.666 * 4.5 × 10 -6
   Independently Average FST 2454 0.15 * 0.628
  tagSNPs By Gene Average FST 24 0.453 0.280
   Independently Average FST 486 0.063 * 6.85 × 10 -4
  1. a Pooling by gene tests average genic FST, while in pooling independently each SNP has been assigned the replicability from the association it belongs to
  2. b Variable indicates which parameter (either average or variance in FST) has been tested versus ϕ
  3. c Conservative set contains those associations that have a replicability of ≥50% in at least one continent
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