Recent human evolution has shaped geographical differences in susceptibility to disease

BMC Genomics

Table 1 Summary of Spearman's correlation coefficients between F_ST and ϕ as the discordance in replicabilities for the 37 associations from the Continental Set

ASSOCIATIONS	CATHEGORY	POOLING^a	VARIABLE^b	N		P value
Full Set	All SNPs	By Gene	Average F_ST	33	0.496 *	0.003
			Variance F_ST	32	0.636 *	7 × 10 ^-5
		Independently	Average F_ST	3710	0.155 *	2.58 × 10 ^-21
	tagSNPs	By Gene	Average F_ST	33	0.187	0.313
		Independently	Average F_ST	538	0.16 *	2.02 × 10 ^-4
Conservative Set^c	All SNPs	By Gene	Average F_ST	26	0.666 *	0.0002
			Variance F_ST	24	0.666 *	4.5 × 10 ^-6
		Independently	Average F_ST	2454	0.15 *	0.628
	tagSNPs	By Gene	Average F_ST	24	0.453	0.280
		Independently	Average F_ST	486	0.063 *	6.85 × 10 ^-4

^a Pooling by gene tests average genic F_ST, while in pooling independently each SNP has been assigned the replicability from the association it belongs to
^b Variable indicates which parameter (either average or variance in F_ST) has been tested versus ϕ
^c Conservative set contains those associations that have a replicability of ≥50% in at least one continent

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