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Table 1 Genes known to be regulated by NGF withdrawal

From: Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death

Gene symbols Gene name -NGF
v
+NGF
CEP
v
+NGF
Pathway References
Bid3/Dp5/Hrk BH3-interacting domain-containing protein 3; Dp5; harakiri 9.78 5.28 cell death 32, 34
Trib3 tribbles homologue 3 (Drosophila) 5.21 1.81 ER stress 35
Dusp1/Mkp1 dual specificity phosphatase 1;MAP kinase phosphatase 1 4.69 1.60 MAPK pathways 13, 24
Bcl2l11/Bim/Bod BCL2-like 11 (apoptosis facilitator) 4.35 1.95 cell death 16, 17
Egln3/SM-20 EGL nine homologue 3 (C. elegans) 3.41 3.53 cell death 15
Gadd45γ growth arrest and DNA-damage- inducible protein 45 gamma 3.16 1.31 DNA damage inducible 33
Jun Jun oncogene; c-Jun 2.62 1.55 AP1 family 13, 14
Ccnd1 cyclin D1 1.46 1.04 cell cycle 31
Myc myelocytomatosis viral oncogene homologue (avian); c-Myc -1.76 -1.32 Myc network 31
Ngfr/p75 NTR nerve growth factor receptor (TNFR superfamily, member 16); p75NTR -1.73 -1.44 neurotrophin signalling 31
  1. The fold increase in RNA level after NGF withdrawal or after NGF withdrawal in the presence of CEP-11004 (average of 3 independent experiments) from the microarray is shown for genes that have been previously reported to be transcriptionally regulated in this system (see references above).