Table 2 Selection of genes regulated by NGF withdrawal identified in this study
GO pathway | Gene symbol | Gene name | -NGF v +NGF | CEP v +NGF |
|---|---|---|---|---|
AP1/ATF family | CREM | cAMP responsive element modulator | 1.51 | 1.25 |
| Â | JunD | Jun D proto-onocogene | 1.74 | 1.60 |
Cell death | Bmf | Bcl2 modifying factor | 1.91 | 1.31 |
| Â | Casp12 | caspase 12 | 1.46 | 1.23 |
| Â | Casp3 | caspase 3, apoptosis related cysteine protease | 1.73 | 1.31 |
| Â | Casp4 | caspase 4, apoptosis related cysteine protease | 1.60 | 1.03 |
| Â | Cycs | cytochrome c, somatic | -1.88 | -1.19 |
DNA damage-inducible | GADD45α | Growth arrest and DNA damage-inducible 45 alpha | 1.45 | 1.41 |
ER stress | ATF3 | activating transcription factor 3 | 2.89 | -1.69 |
| Â | Ddit3 | DNA damage-inducible transcript 3/CHOP10 | 4.11 | 1.37 |
| Â | Eif2ak3 | eukaryotic translation initiation factor 2 alpha kinase 3/PERK | 2.28 | 1.54 |
| Â | Herpud1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 2.17 | 1.17 |
| Â | Myd116 | myeloid differentiation primary response gene 116 | 1.81 | 1.09 |
Fatty acid/cholesterol metabolism | Hmgcr | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | -2.79 | -1.76 |
| Â | Insig1 | insulin induced gene 1 | -4.69 | -1.51 |
| Â | Sc4mol | sterol-C4-methyl oxidase-like | -3.95 | -1.36 |
FOXO target | Txnip | thioredoxin interacting protein/Vdup1 | 3.68 | 2.46 |
MAPK pathways | Dusp6 | dual specificity phosphatase 6/Mkp3 | -6.68 | -5.66 |
| Â | RhoQ | Ras homologue gene family, member Q | 2.51 | 1.16 |
Miscellaneous | Areg | amphiregulin | -5.90 | -5.50 |
| Â | Bhlhb2 | basic helix-loop-helix domain containing, class B2 | -2.35 | -2.36 |
| Â | Btg1 | B-cell translocation gene 1, anti-proliferative | 1.78 | 1.44 |
| Â | Btg2 | B-cell translocation gene 2, anti-proliferative | 3.63 | 1.64 |
| Â | Chrna7 | cholinergic receptor, nicotinic, alpha polypeptide 7 | 2.16 | 2.16 |
| Â | Cnskr3 | Cnksr family member 3 (Magi1) | 3.14 | 1.54 |
| Â | Pkib | protein kinase (cAMP-dependent, catalytic) inhibitor beta | 2.39 | 1.02 |
| Â | Tpo1 | developmentally regulated protein TPO1 | 2.41 | 2.04 |
Myc network | Id2 | Inhibitor of DNA binding 2 | -1.75 | -1.31 |
| Â | Mxi1 | Max interacting protein 1 | 2.22 | 1.77 |
| Â | Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived | -2.89 | -1.87 |
| Â | Ndrg1 | N-myc downstream regulated gene 1 | 3.18 | 2.07 |
| Â | Ptma | prothymosin alpha | -1.93 | -1.37 |
PI3K-Akt | PIK3IP1 | similar to HGFL protein | 5.28 | 4.56 |
pathway | PIK3r1 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1/p85 | 1.85 | 1.90 |