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Table 4 Unique genes with decreased expression in spleen after SGIV infection

From: Transcriptome analysis of orange-spotted grouper (Epinephelus coioides) spleen in response to Singapore grouper iridovirus

swissprot_annotation species Expression in control Expression in infection Fisher p_value
H-2 class II histocompatibility antigen Mus musculus 11365 1044 0
Glutathione peroxidase 1 Bos taurus 3469 509 0
Endothelial differentiation-related factor 1 Xenopus laevis 5830 172 0
Inositol-3-phosphate synthase 1-A Xenopus laevis 1618 148 0
Palmitoyl-protein thioesterase 1 Mus musculus 6570 92 0
Proteasome subunit beta type-2 Bos taurus 2244 84 0
Cytochrome c oxidase subunit 1 Gadus morhua 7690 66 0
Myosin light polypeptide 6 Rattus norvegicus 1733 65 0
Eukaryotic translation initiation factor 3 subunit Danio rerio 1765 60 0
Gamma-interferon-inducible lysosomal thiol reductase Homo sapiens 2962 55 0
Mid1-interacting protein 1-like Danio rerio 3667 54 0
Elongation factor 1-gamma Carassius auratus 1821 51 0
Plastin-2 Danio rerio 1777 51 0
ribosomal protein S8 Rattus norvegicus 1737 48 0
Stefin-C Bos taurus 1991 46 0
Complement C1q subcomponent subunit A Bos taurus 1511 43 0
ribosomal protein L22 Xenopus tropicalis 2286 33 0
ribosomal protein L18 Oreochromis niloticus 1598 29 0
Nucleolar protein 16 Tetraodon nigroviridis 1949 377 9.53E-251
Transcription initiation factor TFIID Pongo abelii 2123 469 6.58E-246
Transforming protein RhoA Rattus norvegicus 1258 202 4.46E-184
Peroxiredoxin Cynops pyrrhogaster 2563 982 7.87E-157
Myosin regulatory light chain 2 Gallus gallus 5634 3124 2.64E-154
Heat shock 70 kDa protein Canis familiaris 612 31 7.54E-140
Ras-related C3 botulinum toxin substrate 2 Bos taurus 928 167 1.56E-126
SH3 domain-containing protein Mus musculus 609 48 1.33E-123
Rab GDP dissociation inhibitor beta Rattus norvegicus 602 48 9.70E-122
Cystatin-A5 Sus scrofa 2339 994 4.94E-120
Radixin Mus musculus 675 77 8.53E-119
Interferon-inducible GTPase 1 Homo sapiens 805 181 4.16E-93
C-X-C chemokine receptor type 4 Papio anubis 1929 851 1.51E-92
AIG2-like domain-containing protein Danio rerio 617 128 1.59E-76
Major complex class I-related gene Mus musculus 1058 366 1.83E-76
Thioredoxin-dependent peroxide reductase, Homo sapiens 769 209 1.20E-74
Death-associated protein-like 1-B Xenopus laevis 1417 638 9.05E-66
RING finger protein 10 Mus musculus 277 24 3.52E-55
Mannan-binding lectin serine protease 2 Mus musculus 2177 1249 6.20E-55
GTP-binding nuclear protein Salmo salar 3669 2432 9.56E-54
Regulator of G-protein signaling 8 Danio rerio 1206 639 6.61E-39
Matrix metalloproteinase-9 Homo sapiens 199 21 2.33E-37
Bleomycin hydrolase Gallus gallus 418 125 2.50E-37
Src kinase-associated phosphoprotein 2 Takifugu rubripes 257 47 8.27E-36
Interferon-induced protein 44-like Mus musculus 352 94 1.44E-35
Protein disulfide-isomerase A4 Rattus norvegicus 191 21 2.56E-35
Macrophage mannose receptor 1 Homo sapiens 257 49 8.14E-35
Prothymosin alpha-B Danio rerio 186 21 4.75E-34
Ubiquitin-conjugating enzyme E2 Drosophila melanogaster 344 97 6.36E-33
Myosin-8 Canis familiaris 1023 547 1.60E-32
cAMP-responsive element-binding protein Danio rerio 684 312 8.58E-32
Programmed cell death protein 10 Mus musculus 383 123 1.42E-31
Peroxisomal membrane protein 2 Bos taurus 612 267 3.46E-31
E3 ubiquitin-protein ligase Homo sapiens 220 41 2.02E-30
Myoferlin Xenopus tropicalis 262 62 4.71E-30
Ras-related protein Rab7 Gossypium hirsutum 223 50 6.44E-27
Dynactin subunit 6 Homo sapiens 242 61 2.40E-26
protease regulatory subunit 4 Rattus norvegicus 229 55 4.43E-26
Interferon regulatory factor 1 Gallus gallus 446 183 1.06E-25
Hephaestin-like protein 1 Mus musculus 276 88 2.05E-23
Galectin-8 Homo sapiens 158 29 1.39E-22
Apoptosis-associated speck-like protein Danio rerio 497 233 2.41E-22