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Table 1 Functions of the genes involved in methionine utilization

From: The MetJ regulon in gammaproteobacteria determined by comparative genomics methods

gene function1
Regulators
metJ AdoMet-dependent transcriptional repressor
metR homocysteine-dependent transcriptional activator
Biosynthetic enzymes
metL aspartokinase II/homoserine dehydrogenase II
metA homoserine O-succinyltransferase
metX homoserine O-acetyltransferase
metY ~O-acetylhomoserine sulfhydrylase
metB cystathionine gamma-synthase
metC cystathionine beta-lyase
metF 5,10-methylenetetrahydrofolate reductase
metH methionine synthase (B12-dependent)
metE methionine synthase (B12-independent)
metK S-adenosylmethionine (AdoMet) synthetase
Methionine salvage pathway genes
ybdH ~alcohol dehydrogenase
mtrA ~MTR transporter (ATPase subunit)
mtrC ~MTR transporter (permease subunit)
mtrB ~MTR transporter (substrate-binding subunit)
mtrY ~function unknown
mtnK 5-methylthioribose (MTR) kinase
mtnA S-methyl-5-thioribose-1-phosphate isomerase
mtnD 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
mtnC 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
mtnB methylthioribulose-1-phosphate dehydratase
mtnE methionine aminotransferase
mtnU ~nitrilase
Transporters
metN methionine transporter (ATPase subunit)
metI methionine transporter (permease subunit)
metQ methionine transporter (substrate-binding subunit)
metT ~methionine transporter (Na+/H+ antiporter family)
btuB vitamin B12 (cobalamin) outer membrane transporter
mtsA ~cobalt transporter (substrate-binding subunit)
mtsB ~cobalt transporter (ATPase subunit)
mtsC ~cobalt transporter (permease subunit)
nhaP ~Na+/H+ antiporter
Other regulated genes
mmuP S-methylmethionine permease
mmuM S-methylmethionine : homocysteine methyltransferase
MHT1 ~homocysteine S-methyltransferase
dppA ~transporter (substrate-binding subunit)
dppB ~transporter (permease subunit)
dppC ~transporter (permease subunit)
dppD ~transporter (ATPase subunit)
MHT2 ~homocysteine S-methyltransferase
arcD ~amino acid permease
metE2a ~methionine synthetase (B12-independent)
mtcB cystathionine beta-synthase
mtcC cystathionine gamma-lyase
megL ~methionine gamma-lyase
pcbC ~oxygenase
Various unregulated genes
ahcY adenosylhomocysteinease
asd aspartate semialdehyde dehydrogenase
def peptide deformylase
fmt 10-formyltetrahydrofolate : L-methionyl-tRNAfMet N-formyltransferase
folE GTP cyclohydrolase I
glyA serine hydroxymethyltransferase
luxS S-ribosylhomocysteine lyase
map methionine aminopeptidase
metG methionyl-tRNA synthetase
mtnN methylthioadenosine (MTA) nucleosidase/S-adenosylhomocysteine (AdoHcy) nucleosidase
  1. 1 Functions predicted from sequence similarity are marked with a tilde (~).