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Table 3 Genes regulated 8 hours following dexamethasone treatment.

From: Evaluation of the NOD/SCID xenograft model for glucocorticoid-regulated gene expression in childhood B-cell precursor acute lymphoblastic leukemia

ProbeSet ID Gene t P FDR Definition
Upregulated      
ILMN_5080450 ZBTB16 83.77 < 2.2E-16 < 2.2E-16 zinc finger and BTB domain containing 16
ILMN_3800088 MMP7 53.22 < 2.2E-16 < 2.2E-16 matrix metallopeptidase 7
ILMN_1770593 CH25H 53.14 < 2.2E-16 < 2.2E-16 cholesterol 25-hydroxylase
ILMN_6560328 C6orf85 44.60 < 2.2E-16 < 2.2E-16 chromosome 6 open reading frame 85
ILMN_7570561 TSC22D3 39.16 < 2.2E-16 < 2.2E-16 TSC22 domain family, member 3
ILMN_580187 PDE8B 33.88 < 2.2E-16 3.90E-16 phosphodiesterase 8B
ILMN_5130066 C8orf61 33.82 < 2.2E-16 3.90E-16 chromosome 8 open reading frame 61
ILMN_4120431 TMEM100 31.38 < 2.2E-16 1.64E-15 transmembrane protein 100
ILMN_650553 BIN1 29.76 < 2.2E-16 4.43E-15 bridging integrator 1
ILMN_1400373 SLA 29.57 < 2.2E-16 4.63E-15 Src-like-adaptor
ILMN_6330593 PTHR1 29.28 < 2.2E-16 5.22E-15 parathyroid hormone receptor 1
ILMN_6110037 LILRA3 29.04 < 2.2E-16 5.75E-15 leukocyte immunoglobulin-like receptor subfamily A, member 3
ILMN_4150477 LOXL4 28.67 < 2.2E-16 6.66E-15 lysyl oxidase-like 4
ILMN_2680079 OGFRL1 28.65 < 2.2E-16 6.66E-15 opioid growth factor receptor-like 1
ILMN_4210411 NDRG2 28.20 < 2.2E-16 8.62E-15 NDRG family member 2
ILMN_3780093 LILRA1 27.86 < 2.2E-16 1.05E-14 leukocyte immunoglobulin-like receptor subfamily A, member 1
ILMN_240441 IL1R2 27.46 < 2.2E-16 1.33E-14 interleukin 1 receptor, type II
ILMN_4730315 MERTK 26.14 < 2.2E-16 3.31E-14 c-mer proto-oncogene tyrosine kinase
ILMN_3800538 ACPL2 25.90 < 2.2E-16 3.72E-14 acid phosphatase-like 2
ILMN_6860392 UGT2B17 25.83 < 2.2E-16 3.72E-14 UDP glucuronosyltransferase 2 family, polypeptide B17
ILMN_4730541 SLC44A1 25.82 < 2.2E-16 3.72E-14 solute carrier family 44, member 1
ILMN_4860546 CTHRC1 25.64 < 2.2E-16 4.10E-14 collagen triple helix repeat containing 1
ILMN_3460270 ZHX3 24.56 < 2.2E-16 8.79E-14 zinc fingers and homeoboxes 3
ILMN_10639 RASSF4 23.21 < 2.2E-16 2.57E-13 Ras association (RalGDS/AF-6) domain family 4
ILMN_1190064 UGT2B7 23.13 < 2.2E-16 2.67E-13 UDP glucuronosyltransferase 2 family, polypeptide B7
ILMN_6400603 MGC2463 23.06 < 2.2E-16 2.71E-13 poliovirus receptor related immunoglobulin domain containing
ILMN_3450187 IRGM 23.04 < 2.2E-16 2.71E-13 immunity-related GTPase family, M
ILMN_6620528 MT1X 22.95 2.40E-16 2.85E-13 metallothionein 1X
ILMN_1260341 IL13RA1 22.47 3.67E-16 4.13E-13 interleukin 13 receptor, alpha 1
ILMN_2650112 SLC16A2 22.25 4.48E-16 4.91E-13 solute carrier family 16, member 2
ILMN_5570170 PNMT 22.01 5.59E-16 5.95E-13 phenylethanolamine N-methyltransferase
ILMN_870376 C9orf152 21.93 6.02E-16 6.25E-13 chromosome 9 open reading frame 152
ILMN_3190379 TGFBR3 21.52 8.78E-16 8.89E-13 transforming growth factor, beta receptor III
ILMN_1780142 DSCR1 21.08 1.33E-15 1.31E-12 Down syndrome critical region gene 1
ILMN_2640341 FKBP5 20.63 2.05E-15 1.89E-12 FK506 binding protein 5
ILMN_7610136 LOC652626 20.43 2.48E-15 2.23E-12 Leukocyte immunoglobulin-like receptor subfamily B member 2
ILMN_1410609 CORO2A 20.34 2.72E-15 2.35E-12 coronin, actin binding protein, 2A
ILMN_1780088 TBXA2R 20.29 2.84E-15 2.40E-12 thromboxane A2 receptor
ILMN_270431 BAALC 20.23 3.02E-15 2.50E-12 brain and acute leukemia, cytoplasmic
ILMN_6280176 GBE1 20.02 3.72E-15 3.01E-12 glucan (1,4-alpha-), branching enzyme 1
ILMN_6060113 TBX15 19.81 4.62E-15 3.67E-12 T-box 15
ILMN_4890743 IQSEC1 19.71 5.09E-15 3.97E-12 IQ motif and Sec7 domain 1
ILMN_150056 DPEP1 19.65 5.41E-15 4.13E-12 dipeptidase 1
ILMN_2060364 BTNL9 19.26 8.04E-15 5.91E-12 butyrophilin-like 9
ILMN_3830735 UPB1 19.23 8.30E-15 5.91E-12 ureidopropionase, beta
ILMN_5670377 STYK1 19.15 9.09E-15 6.35E-12 serine/threonine/tyrosine kinase 1
ILMN_4390630 STAG3 18.72 1.42E-14 9.39E-12 stromal antigen 3
ILMN_4070048 NPHP4 18.44 1.91E-14 1.25E-11 nephronophthisis 4
ILMN_4220474 C6orf81 18.31 2.16E-14 1.39E-11 chromosome 6 open reading frame 81
ILMN_1470746 PTPN3 18.30 2.23E-14 1.41E-11 protein tyrosine phosphatase, non-receptor type 3
ILMN_5860576 C20orf133 18.25 2.36E-14 1.47E-11 MACRO domain containing 2
ILMN_6020468 PPP1R14A 18.18 2.52E-14 1.55E-11 protein phosphatase 1, regulatory (inhibitor) subunit 14A
ILMN_1400634 MT1M 18.10 2.76E-14 1.64E-11 metallothionein 1M
ILMN_4250315 ITGA9 17.90 3.46E-14 2.03E-11 integrin, alpha 9
ILMN_5080471 MAP3K6 17.40 6.02E-14 3.44E-11 mitogen-activated protein kinase 6
ILMN_5360242 FLJ42461 17.36 6.28E-14 3.53E-11 smoothelin-like 2
ILMN_6620402 NUDT16 17.33 6.50E-14 3.60E-11 nudix (nucleoside diphosphate linked moiety X)-type motif 16
ILMN_3360112 TMEM2 17.26 7.04E-14 3.85E-11 transmembrane protein 2
ILMN_6840743 PER1 17.22 7.41E-14 3.99E-11 period homolog 1
ILMN_4220347 LRRC1 17.12 8.29E-14 4.33E-11 leucine rich repeat containing 1
ILMN_4850592 P2RY14 17.11 8.35E-14 4.33E-11 purinergic receptor P2Y, G-protein coupled, 14
ILMN_6560300 SLC31A2 16.91 1.05E-13 5.39E-11 solute carrier family 31 member 2
ILMN_4060091 DKFZ 16.87 1.11E-13 5.62E-11 DKFZp451A211 protein
ILMN_6770370 LOC92196 16.28 2.23E-13 1.11E-10 death associated protein-like 1
ILMN_580487 IL9R 16.21 2.40E-13 1.18E-10 interleukin 9 receptor
ILMN_1990300 SOCS1 16.18 2.49E-13 1.21E-10 suppressor of cytokine signaling 1
ILMN_5720424 NRP1 16.17 2.54E-13 1.22E-10 neuropilin 1
ILMN_4180427 CIB4 16.11 2.74E-13 1.30E-10 calcium and integrin binding family member 4
ILMN_4180544 ROPN1L 16.08 2.81E-13 1.32E-10 ropporin 1-like
ILMN_4250167 SOX13 16.04 2.95E-13 1.37E-10 SRY (sex determining region Y)-box 13
ILMN_6330170 CHKA 15.81 3.94E-13 1.81E-10 choline kinase alpha, 3
ILMN_4560192 SFXN5 15.62 4.95E-13 2.25E-10 sideroflexin 5
ILMN_2810136 CAPN11 15.56 5.33E-13 2.40E-10 calpain 11
ILMN_2690709 VIPR1 15.38 6.68E-13 2.91E-10 vasoactive intestinal peptide receptor 1
ILMN_630091 NCOA7 15.38 6.69E-13 2.91E-10 nuclear receptor coactivator 7
ILMN_5390730 MGC17330 15.21 8.25E-13 3.55E-10 phosphoinositide-3-kinase interacting protein 1
ILMN_130364 MST150 15.19 8.49E-13 3.62E-10 MSTP150
ILMN_3450241 KIAA0774 14.95 1.16E-12 4.77E-10 KIAA0774
ILMN_2230678 ACACB 14.80 1.41E-12 5.76E-10 acetyl-Coenzyme A carboxylase beta
ILMN_5870307 LOC440359 14.78 1.44E-12 5.83E-10 similar to muscle Y-box protein YB2
ILMN_3840554 SPOCK2 14.76 1.49E-12 5.95E-10 sparc/osteonectin, cwcv and kazal-like domains 2
ILMN_5810600 MAP3K5 14.69 1.63E-12 6.47E-10 mitogen-activated protein kinase 5
ILMN_2360719 IRAK3 14.65 1.71E-12 6.65E-10 interleukin-1 receptor-associated kinase 3
ILMN_1510121 MTSS1 14.64 1.73E-12 6.66E-10 metastasis suppressor 1
ILMN_540671 LILRB2 14.54 1.98E-12 7.41E-10 leukocyte immunoglobulin-like receptor subfamily B, member 2
ILMN_6980377 MTMR15 14.44 2.26E-12 8.39E-10 myotubularin related protein 15
ILMN_6220288 PRDM1 14.43 2.28E-12 8.39E-10 PR domain containing 1, with ZNF domain
ILMN_7330739 NDRG4 14.42 2.30E-12 8.39E-10 NDRG family member 4
ILMN_2600470 WDR60 14.20 3.10E-12 1.12E-09 WD repeat domain 60
ILMN_4050441 SH3MD4 14.16 3.27E-12 1.17E-09 SH3 multiple domains 4
ILMN_6760546 TIPARP 13.89 4.74E-12 1.64E-09 TCDD-inducible poly(ADP-ribose) polymerase
ILMN_2760537 MTE 13.89 4.75E-12 1.64E-09 metallothionein E
ILMN_160019 SORT1 13.79 5.44E-12 1.83E-09 sortilin 1
ILMN_6330132 ISG20 13.60 7.00E-12 2.32E-09 interferon stimulated exonuclease gene 20 kDa
ILMN_1510685 DOK4 13.52 7.86E-12 2.58E-09 docking protein 4
ILMN_1240228 PAG1 13.47 8.50E-12 2.77E-09 phosphoprotein associated glycosphingolipid microdomains 1
ILMN_580592 CPNE8 13.32 1.04E-11 3.31E-09 copine VIII
ILMN_5870301 KIAA0513 13.32 1.05E-11 3.31E-09 KIAA0513
ILMN_20129 CD52 13.32 1.05E-11 3.31E-09 CD52 molecule
ILMN_1820386 PARVB 13.31 1.06E-11 3.31E-09 parvin, beta
ILMN_6200402 MT1A 13.24 1.17E-11 3.64E-09 metallothionein 1A
ILMN_290661 CLN8 13.10 1.43E-11 4.36E-09 ceroid-lipofuscinosis, neuronal 8
ILMN_670082 GNA12 13.08 1.47E-11 4.43E-09 guanine nucleotide binding protein (G protein) alpha 12
ILMN_5570286 TACC2 12.99 1.67E-11 5.00E-09 transforming, acidic coiled-coil containing protein 2
ILMN_3190411 STARD13 12.93 1.81E-11 5.32E-09 START domain containing 13
ILMN_4540138 NGB 12.92 1.85E-11 5.39E-09 neuroglobin
ILMN_2000646 B4GALT4 12.83 2.10E-11 6.07E-09 UDP-galactosyltransferase, polypeptide 4
ILMN_7100731 CYGB 12.81 2.17E-11 6.17E-09 cytoglobin
ILMN_7050113 NTRK1 12.71 2.52E-11 7.09E-09 neurotrophic tyrosine kinase receptor, type 1
ILMN_2490670 GNPTAB 12.66 2.71E-11 7.52E-09 N-acetylglucosamine-1-phosphate transferase, alpha and beta
ILMN_20170 ZNF385 12.48 3.55E-11 9.72E-09 zinc finger protein 385
ILMN_2630687 CHPT1 12.43 3.80E-11 1.02E-08 choline phosphotransferase 1
ILMN_4120215 WASF2 12.43 3.81E-11 1.02E-08 WAS protein family, member 2
ILMN_5260494 TMLHE 12.39 4.06E-11 1.08E-08 trimethyllysine hydroxylase, epsilon
ILMN_5220333 C14orf139 12.31 4.54E-11 1.20E-08 chromosome 14 open reading frame 139
ILMN_3850440 FCER1G 12.12 6.07E-11 1.60E-08 Fc fragment of IgE, receptor for; gamma polypeptide
ILMN_1030008 TGFB3 12.11 6.21E-11 1.63E-08 transforming growth factor, beta 3
ILMN_1450468 MYT1 12.02 7.04E-11 1.81E-08 myelin transcription factor 1
ILMN_7560541 SLC2A5 12.01 7.19E-11 1.83E-08 solute carrier family 2 member 5
ILMN_2030438 GBA2 12.01 7.21E-11 1.83E-08 glucosidase, beta (bile acid) 2
ILMN_6840328 SMAD3 12.00 7.35E-11 1.86E-08 SMAD family member 3
ILMN_3930390 SMAP1L 11.91 8.40E-11 2.11E-08 stromal membrane-associated protein 1-like
ILMN_7570196 TSPAN9 11.90 8.54E-11 2.12E-08 tetraspanin 9
ILMN_6980546 CACNA1I 11.90 8.56E-11 2.12E-08 calcium channel, voltage-dependent, T type, alpha 1I subunit
ILMN_1710364 LCN6 11.89 8.72E-11 2.15E-08 lipocalin 6
ILMN_5360424 RPS6KA2 11.77 1.04E-10 2.54E-08 ribosomal protein S6 kinase, 90 kDa, polypeptide 2
ILMN_5890193 MS4A4A 11.72 1.14E-10 2.75E-08 membrane-spanning 4-domains, subfamily A, member 4
ILMN_3390292 KLF9 11.66 1.24E-10 2.98E-08 Kruppel-like factor 9
ILMN_5720059 GFOD1 11.65 1.26E-10 3.02E-08 glucose-fructose oxidoreductase domain containing 1
ILMN_7650523 TMEM46 11.57 1.43E-10 3.39E-08 transmembrane protein 46
ILMN_5700392 LOC654000 11.46 1.70E-10 3.95E-08 ribosome biogenesis protein BMS1 homolog 2
ILMN_4810348 C1orf188 11.40 1.88E-10 4.33E-08 chromosome 1 open reading frame 188
ILMN_4280180 CHRNA3 11.39 1.91E-10 4.37E-08 cholinergic receptor, nicotinic, alpha 3
ILMN_270458 CRISPLD1 11.37 1.96E-10 4.45E-08 cysteine-rich secretory protein LCCL domain containing 1
ILMN_450615 MT2A 11.37 1.97E-10 4.46E-08 metallothionein 2A
ILMN_20470 GRASP 11.35 2.02E-10 4.51E-08 GRP1-associated scaffold protein
ILMN_3370594 LILRA2 11.35 2.03E-10 4.51E-08 leukocyte immunoglobulin-like receptor subfamily A, member 2
ILMN_5220397 RREB1 11.34 2.05E-10 4.53E-08 ras responsive element binding protein 1
ILMN_1410192 TDRD9 11.34 2.07E-10 4.56E-08 tudor domain containing 9
ILMN_4070259 LOC653133 11.27 2.30E-10 4.99E-08 guanine nucleotide binding protein (G protein) alpha 12
ILMN_5960682 RBPMS2 11.24 2.41E-10 5.21E-08 RNA binding protein with multiple splicing 2
ILMN_1440300 SLC27A3 11.22 2.50E-10 5.37E-08 solute carrier family 27, member 3
ILMN_5050768 LONRF1 11.20 2.58E-10 5.53E-08 LON peptidase N-terminal domain and ring finger 1
ILMN_6270273 KHDRBS3 11.18 2.67E-10 5.68E-08 KH domain, RNA binding, signal transduction associated 3
ILMN_7100603 KCNK3 11.17 2.70E-10 5.72E-08 potassium channel, subfamily K, member 3
ILMN_2320129 CSDA 11.03 3.38E-10 7.08E-08 cold shock domain protein A
ILMN_3930022 LOC644739 10.99 3.63E-10 7.54E-08 Wiskott-Aldrich syndrome protein family member 4
ILMN_7400133 CUGBP2 10.90 4.20E-10 8.63E-08 CUG triplet repeat, RNA binding protein 2
ILMN_3290301 FZD8 10.88 4.33E-10 8.76E-08 frizzled homolog 8
ILMN_7320520 MTUS1 10.88 4.33E-10 8.76E-08 mitochondrial tumor suppressor 1
ILMN_3780053 PALLD 10.82 4.79E-10 9.60E-08 palladin, cytoskeletal associated protein
ILMN_6860162 LOC441019 10.74 5.49E-10 1.09E-07 hypothetical LOC441019
ILMN_5810154 ALOX15B 10.74 5.50E-10 1.09E-07 arachidonate 15-lipoxygenase, type B
ILMN_3930736 CHST3 10.73 5.59E-10 1.09E-07 carbohydrate (chondroitin 6) sulfotransferase 3
ILMN_60470 STX11 10.72 5.68E-10 1.10E-07 syntaxin 11
ILMN_3390484 SERINC2 10.69 5.95E-10 1.15E-07 serine incorporator 2
ILMN_1430647 TAX1BP3 10.61 6.82E-10 1.31E-07 Tax1 (human T-cell leukemia virus type I) binding protein 3
ILMN_5960440 VDR 10.60 6.99E-10 1.34E-07 vitamin D (1,25-dihydroxyvitamin D3) receptor
ILMN_6290735 EPHB3 10.51 8.10E-10 1.53E-07 EPH receptor B3
ILMN_2680372 SH2D4A 10.46 8.78E-10 1.64E-07 SH2 domain containing 4A
ILMN_2480050 SOX7 10.44 9.13E-10 1.69E-07 SRY (sex determining region Y)-box 7
ILMN_130128 LOC285016 10.41 9.61E-10 1.76E-07 hypothetical protein LOC285016
ILMN_4890451 GRAMD3 10.39 9.87E-10 1.80E-07 GRAM domain containing 3
ILMN_770161 C10orf73 10.39 9.92E-10 1.81E-07 chromosome 10 open reading frame 73
ILMN_2450202 KIF3C 10.35 1.05E-09 1.88E-07 kinesin family member 3C
ILMN_6840468 HAL 10.35 1.06E-09 1.89E-07 histidine ammonia-lyase
ILMN_2470070 TBL1X 10.30 1.15E-09 2.04E-07 transducin (beta)-like 1X-linked
ILMN_2320114 KLF13 10.27 1.22E-09 2.15E-07 Kruppel-like factor 13
ILMN_6380112 DIP 10.23 1.31E-09 2.27E-07 death-inducing-protein
ILMN_2470358 IFNGR1 10.22 1.32E-09 2.30E-07 interferon gamma receptor 1
ILMN_4250735 IL27RA 10.07 1.70E-09 2.91E-07 interleukin 27 receptor, alpha
ILMN_1470215 MAP3K8 10.07 1.72E-09 2.91E-07 mitogen-activated protein kinase 8
ILMN_2940373 TACC1 10.06 1.74E-09 2.94E-07 transforming, acidic coiled-coil containing protein 1
Downregulated      
ILMN_770538 LYSMD2 -15.49 5.81E-13 2.58E-10 LysM, putative peptidoglycan-binding, domain containing 2
ILMN_7150059 STAMBPL1 -14.61 1.79E-12 6.84E-10 STAM binding protein-like 1
ILMN_5340692 STRBP -14.56 1.93E-12 7.31E-10 spermatid perinuclear RNA binding protein
ILMN_4210397 GLDC -14.05 3.80E-12 1.34E-09 glycine dehydrogenase
ILMN_6980327 DKC1 -13.79 5.44E-12 1.83E-09 dyskeratosis congenita 1, dyskerin
ILMN_50086 TCF12 -13.23 1.19E-11 3.69E-09 transcription factor 12
ILMN_4860356 BYSL -12.81 2.17E-11 6.17E-09 bystin-like
ILMN_4280228 IVNS1ABP -12.70 2.55E-11 7.12E-09 influenza virus NS1A binding protein
ILMN_1990379 SLFN11 -11.82 9.63E-11 2.36E-08 schlafen family member 11
ILMN_5220338 MPEG1 -11.64 1.27E-10 3.03E-08 macrophage expressed gene 1
ILMN_450168 SFRS7 -11.50 1.60E-10 3.74E-08 splicing factor, arginine/serine-rich 7, 35 kDa
ILMN_3460687 KIAA0690 -11.42 1.81E-10 4.19E-08 ribosomal RNA processing 12 homolog
ILMN_3400360 MAPRE2 -11.36 1.99E-10 4.48E-08 microtubule-associated protein, RP/EB family, member 2
ILMN_4010414 PPFIBP1 -11.12 2.92E-10 6.16E-08 PTPRF interacting protein, binding protein 1 (liprin beta 1)
ILMN_1190139 UGT3A2 -10.99 3.61E-10 7.54E-08 UDP glycosyltransferase 3 family, polypeptide A2
ILMN_4150201 BCL2 -10.93 3.99E-10 8.24E-08 B-cell CLL/lymphoma 2
ILMN_780240 C12orf24 -10.85 4.53E-10 9.13E-08 chromosome 12 open reading frame 24
ILMN_6760167 MARCH3 -10.73 5.60E-10 1.09E-07 membrane-associated ring finger (C3HC4) 3
ILMN_3940615 PUS7 -10.52 7.99E-10 1.52E-07 pseudouridylate synthase 7 homolog
ILMN_20544 GART -10.41 9.53E-10 1.76E-07 phosphoribosylglycinamide formyltransferase
ILMN_2480326 HSP90B1 -10.36 1.05E-09 1.88E-07 heat shock protein 90 kDa beta (Grp94), member 1
ILMN_5270367 CTSC -10.25 1.26E-09 2.20E-07 cathepsin C
ILMN_5420095 MYC -10.21 1.36E-09 2.34E-07 v-myc myelocytomatosis viral oncogene homolog
ILMN_4610180 PIK3C2B -10.20 1.38E-09 2.37E-07 phosphoinositide-3-kinase, class 2, beta polypeptide
ILMN_6450300 GEMIN4 -10.00 1.95E-09 3.27E-07 gem (nuclear organelle) associated protein 4
  1. t, t-statistic; and FDR, false discovery rate