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Figure 5 | BMC Genomics

Figure 5

From: Horizontal gene transfer in Histophilus somni and its role in the evolution of pathogenic strain 2336, as determined by comparative genomic analyses

Figure 5

Comparison of the chromosomal regions of strains 2336 and 129Pt that encode putative filamentous hemagglutinins and/or subtilisin. The numbers on either side of the maps refer to the nucleotide positions in the respective chromosomes. Although the loci are of different sizes, each map within a locus is drawn to scale. Bold arrows represent genes of interest. Arrows with identical slashes inside them represent orthologous genes among the two strains. Unmarked white arrows represent strain-specific genes, genes found at a different location in the other chromosome, or genes encoding hypothetical proteins. Within each locus, the top portion represents strain 2336 and the bottom portion represents strain 129Pt. Locus I. 1. Hypothetical protein ([GenBank:HSM_0264]), 2. Methylglyoxal synthase, 3. Hypothetical protein ([GenBank:HSM_0266]), 4. Hemolysin activation/secretion protein (fhaC), 5, 6, 7, 8. Filamentous hemagglutinin outer membrane protein (fhaB), t. tRNA, 9. Cystathionine gamma-synthase, 10. Thioredoxin, 11. Chromosomal replication initiator DnaA, 12. Uracil-xanthine permease, 13. Uracil phosphoribosyltransferase, 14. Glutamine amidotransferase class-II, 15. Glutamate dehydrogenase, a,b,c. Chromosome/plasmid partition locus. Locus II. 1. DNA-binding transcriptional activator GutM, 2. Sorbitol-6-phosphate dehydrogenase, 3. PTS system glucitol/sorbitol-specific IIA component, 4. PTS system, glucitol/sorbitol-specific, IIBC subunit, 5. PTS system, glucitol/sorbitol-specific, IIC subunit, A. 153 bp sequence found only in strains 129Pt and 2336, B. 500 bp sequence with homology to type III restriction-modification genes, C. 173 bp sequence found only in strain 129Pt, 6-fhaC, 7. fhaB, T. Transposon-related sequence, 8. UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase, 9. Polyprenyl-6-methoxyphenol 4-hydroxylase, 10. Peptidase M24, 11. YecA family protein, 12. Cell division protein ZapA. Locus III. 1. Biotin synthase, 2. Thiamine ABC transporter, ATP-binding protein, 3. Thiamine ABC transporter, inner membrane subunit, 4. Thiamine ABC transporter, periplasmic binding protein, 5. fhaB, 6. fhaC, 7. Na+ antiporter NhaC, 8. Predicted primosomal replication protein N, 9. ECF subfamily RNA polymerase sigma-24 factor, 10. Oxidoreductase molybdopterin binding, 11. Ferric reductase domain-containing protein, 12. Permease, t. tRNA, 13. Ribosomal RNA large subunit methyltransferase L. Locus IV. 1. O-succinylbenzoate synthase, 2. Naphthoate synthase, 3. Phosphopyruvate hydratase, 4. Type I restriction enzyme, specificity subunit, 5. HsdR family type I site-specific deoxyribonuclease, 6. Abi family protein, 7. Restriction-modification system DNA specificity subunit, 8. Filamentation induced by cAMP protein Fic, 9. Type I restriction-modification system M subunit, 10. Phage integrase family protein, 11. Restriction-modification system DNA specificity subunit, 12. Acyltransferase, 13. Transposase, 14. Transposase, 15, 16, 17, 18, 19, 20. fhaB, 21. fhaC, 22. Hypothetical protein, 23. Ubiquinone/menaquinone biosynthesis methyltransferase, 24. Hypothetical protein, 25. Probable ubiquinone biosynthesis protein ubiB, 26, 27, 28. Twin-arginine translocation proteins, 29. Delta-aminolevulinic acid dehydratase, 30. Phosphoribosylglycinamide formyltransferase, 31. S-ribosylhomocysteine lyase (luxS), 32. Transketolase, 33. CTP synthase, 34. Acetyltransferase, a. Restriction-modification system DNA specificity subunit, b. Phage integrase. Locus V. 1. LysR family transcriptional regulator, 2. Phage repressor, 3. Transposase, 4. Phage transposase, 5. Transposase, 6. DNA methylase, 7. Transposase, 8. Transposase, 9. AAA ATPase, 10. Peptidase S8 and S53 subtilisin kexin sedolisin, 11. Permease DsdX, 12. D-serine dehydratase, 13. DNA topoisomerase III, t. tRNA.

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