Figure 1

Neighbor-joining (NJ) tree of MAPK catalytic domain sequences. Unrooted NJ tree with results from bootstrap NJ analysis indicated for groups with support ≥ 75%. Groupings of the MAPK clades are marked. Abbreviations of species and NCBI accession numbers of MAPK sequences are as follows: Anopheles gambiae (AgERK XP_319983; AgJNKa XP_307879; AgJNKb XP_310236.3; AgM3K12/13 XP_316502.4; AgM4K XP_309868.4; AgM4K4 XP_316357.4; AgMAP2K7 XP_321199.4; AgMEK1 XP_322064.4; AgMEK3/6 XP_310813.4; AgMEKK4 XP_312585.4; AgMEKK5/6 XP_311281.4; AgMKK4 XP_314266.4; AgMLK2/3 XP_312218.4; AgMOS XP_308274.2; AgP38 XP_001689258.1; AgRAFPK XP_318144.4; AgTAK1 AGAP013516-PB (Ensembl ID, no current NCBI accession number)), Caenorhabditis elegans (CeLIN-45 AAR26307; CeGCK2 NP_504721; CeJNK1 NP_001021270; CeMEK1 NP_001024771; CeMEK2 NP_491087; CeMIG15 NP_001024971; CeMKK4 NP_509682; CeMLK1 NP_741537; CeMOM4 NP_492620; CeMPK1 NP_001022583; CeMTK1 NP_491683; CeNSY1 AAK31527; CePMK1 NP_501365; CeSEK1 NP_509322), Ciona intestinalis (CiMAP2K1 BAE06544.1; CiMAP2K3 BAE06545.1; CiMAP2K4 BAE06546.1; CiMAP2K7 BAE06548.1; CiMAP3K4 BAE06549.1; CiMAP3K5 XP_002122959.1; CiMAP3K7 (XP_002130898); CiMAP4K4 XP_002131009; CiMAPK1 BAE06412; CiMAPK7 BAE06414.1; CiMAPK8 BAE06525.1; CiMAPK11 BAE06625.1), Drosophila melanogaster (DmBASKET ACZ94221.1; DmDSOR1 AAF46475.1; DmERK7 AAF46481.2; DmHAPPYHR (happyhour) AAM70845.1; DmHEP (hemipterous) AAG22351.2; DmLICORNE AAF48223.1; DmMEKK1 AAF55592.2; DmMISSHAPE (misshapen) AAS64945.1; DmMKK4 ACZ94848.1; DmMOSPK NP_610817.1; DmMPK2 ACZ95005.1; DmP38b AAF53326.1; DmP38c AAS65203.1; DmPK92 AAF55711.3; DmPOLEHOLE/DmBRAF NP_001036258.1; DmROLLED EDP28108.1; DmSLIPPER AAF46344.3; DmTAK1 AAF50895.1; DmWALLENDA AAO41222.1), Homo sapiens (HsARAF NP_001645.1; HsASK1 NP_005914.1; HsASK2 NP_004663.3; HsASK3 NP_001001671.3; HsBRAF NP_004324.2; HsDLK/ZPK NP_006292.3; HsERK1 NP_002737.2; HsERK2 P28482.3; HsERK3 NP_002739.1; HsERK4 NP_002738.2; HsERK5 NP_002740.2; HsERK7/8 NP_620590.2; HsGCK NP_004570.2; HsGCKR Q9Y4K4.1; HsGLK NP_003609.2; HsHPK1 NP_009112.1; HsJNK1 NP_620637.1; HsJNK2 NP_002743.3; HsJNK3 NP_620448.1; HsMEK1 NP_002746.1; HsMEK2 NP_109587.1; HsMEK3 NP_659731.1; HsMEK4 NP_003001.1; HsMEK5 NP_660143.1; HsMEK6 NP_002749.2; HsMEK7 NP_660186.1; HsMEKK1 NP_005912.1; HsMEKK2 AAH_65755.1; HsMEKK3 NP_976226.1; HsMEKK4 Q9Y6R4.2; HsMLK1 NP_004712.1; HsMLK2 NP_002437.2; HsMLK3 NP_002410.1; HsMOS NP_005363.1; HsNIK NP_003945; HsHGK O95819.2; HsP38alpha NP_620581.1; HsP38beta NP_002742.3; HsP38delta NP_002745.1; HsP38gamma NP_002960.2; HsPRKE1 NP_149132.2; HsRAF1 P04049.1; HsTAK1 NP_663304.1; HsTPL2 NP_005195.2) and Saccharomyces cerevisiae (ScSMK1 856167; ScKSS1 AAZ22456.1). Aligned data and phylogenetic trees are available in TreeBASE http://www.treebase.org as study number S11970.