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Table 1 GO categories enriched in microarray comparisons through gossypol-tissue treatments

From: Transcriptional responses underlying the hormetic and detrimental effects of the plant secondary metabolite gossypol on the generalist herbivore Helicoverpa armigera

  GO accession GO term Corrected p-value
T7- Gut/UP    
  GO:0055114 oxidation reduction 7.19E-19
  GO:0016491 oxidoreductase activity 1.94E-18
  GO:0044429 mitochondrial part 4.01E-15
  GO:0005739 mitochondrion 2.28E-14
  GO:0005740 mitochondrial envelope 1.50E-10
  GO:0031966 mitochondrial membrane 2.77E-09
  GO:0003824 catalytic activity 6.22E-08
  GO:0031967 organelle envelope 6.77E-08
  GO:0005743 mitochondrial inner membrane 7.14E-08
  GO:0019866 organelle inner membrane 7.76E-08
  GO:0031975 envelope 5.36E-07
  GO:0031090 organelle membrane 7.13E-07
  GO:0044444 cytoplasmic part 6.98E-05
  GO:0015992 proton transport 7.52E-05
  GO:0006818 hydrogen transport 8.16E-05
  GO:0006091 generation of precursor metabolites and energy 8.16E-05
  GO:0042180 cellular ketone metabolic process 1.27E-04
  GO:0015077 monovalent inorganic cation transmembrane transporter activity 3.16E-04
  GO:0019752 carboxylic acid metabolic process 3.50E-04
  GO:0043436 oxoacid metabolic process 3.50E-04
  GO:0006082 organic acid metabolic process 3.50E-04
  GO:0005759 mitochondrial matrix 4.27E-04
  GO:0031980 mitochondrial lumen 4.27E-04
  GO:0008610 lipid biosynthetic process 4.81E-04
  GO:0015672 monovalent inorganic cation transport 4.81E-04
  GO:0005506 iron ion binding 7.97E-04
T5 - Rest of body/DOWN    
  GO:0007156 homophilic cell adhesion 1.90E-05
  GO:0016337 cell-cell adhesion 2.83E-04
T7 - Rest of body/DOWN    
  GO:0070003 threonine-type peptidase activity 4.38E-12
  GO:0051603 proteolysis involved in cellular protein catabolic process 3.93E-14
  GO:0051444 negative regulation of ubiquitin-protein ligase activity 3.99E-05
  GO:0051443 positive regulation of ubiquitin-protein ligase activity 1.12E-04
  GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 1.12E-04
  GO:0051438 regulation of ubiquitin-protein ligase activity 1.12E-04
  GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 1.12E-04
  GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 3.99E-05
  GO:0051352 negative regulation of ligase activity 3.99E-05
  GO:0051351 positive regulation of ligase activity 3.00E-04
  GO:0051340 regulation of ligase activity 3.00E-04
  GO:0044265 cellular macromolecule catabolic process 2.67E-11
  GO:0044257 cellular protein catabolic process 3.93E-14
  GO:0043632 modification-dependent macromolecule catabolic process 5.52E-10
  GO:0043234 protein complex 2.38E-08
  GO:0043161 proteasomal ubiquitin-dependent protein catabolic process 1.12E-04
  GO:0031398 positive regulation of protein ubiquitination 1.86E-04
  GO:0031397 negative regulation of protein ubiquitination 3.99E-05
  GO:0031396 regulation of protein ubiquitination 4.83E-04
  GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 3.99E-05
  GO:0030163 protein catabolic process 8.38E-17
  GO:0022624 proteasome accessory complex 4.28E-08
  GO:0019941 modification-dependent protein catabolic process 5.52E-10
  GO:0019773 proteasome core complex, alpha-subunit complex 8.26E-04
  GO:0010498 proteasomal protein catabolic process 1.12E-04
  GO:0009057 macromolecule catabolic process 3.09E-09
  GO:0006511 ubiquitin-dependent protein catabolic process 4.88E-10
  GO:0006508 proteolysis 1.86E-04
  GO:0005839 proteasome core complex 4.38E-12
  GO:0005838 proteasome regulatory particle 6.90E-09
  GO:0004298 threonine-type endopeptidase activity 4.38E-12
  GO:0000502 proteasome complex 2.60E-29
T7 - Rest of body/UP    
  GO:0016491 oxidoreductase activity 9.14E-24
  GO:0055114 oxidation reduction 7.45E-20
  GO:0042302 structural constituent of cuticle 6.83E-13
  GO:0050662 coenzyme binding 1.18E-12
  GO:0048037 cofactor binding 1.18E-12
  GO:0050660 FAD or FADH2 binding 1.16E-08
  GO:0003824 catalytic activity 3.37E-08
  GO:0006066 alcohol metabolic process 2.52E-07
  GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 2.52E-07
  1. Statistically filtered transcriptional responses per H. armigera tissue (Welch's t-test, B&H FDR corrected P < 0.001) relative to gossypol-free diet expression data was subjected to GO enrichment analysis (P < 0.01) using Agilent GeneSpring GX11.5.1 software (Gossypol concentration: T5 = 0.016%, T7 = 0.16%).
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BMC Genomics

ISSN: 1471-2164

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