TY - JOUR AU - Ruvalcaba-Trejo, Laura I. AU - Sturm, Nancy R. PY - 2011 DA - 2011/01/24 TI - The Trypanosoma cruzi Sylvio X10 strain maxicircle sequence: the third musketeer JO - BMC Genomics SP - 58 VL - 12 IS - 1 AB - Chagas disease has a diverse pathology caused by the parasite Trypanosoma cruzi, and is indigenous to Central and South America. A pronounced feature of the trypanosomes is the kinetoplast, which is comprised of catenated maxicircles and minicircles that provide the transcripts involved in uridine insertion/deletion RNA editing. T. cruzi exchange genetic material through a hybridization event. Extant strains are grouped into six discrete typing units by nuclear markers, and three clades, A, B, and C, based on maxicircle gene analysis. Clades A and B are the more closely related. Representative clade B and C maxicircles are known in their entirety, and portions of A, B, and C clades from multiple strains show intra-strain heterogeneity with the potential for maxicircle taxonomic markers that may correlate with clinical presentation. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-12-58 DO - 10.1186/1471-2164-12-58 ID - Ruvalcaba-Trejo2011 ER -