Method Overview. Triangles represent disease genes, rectangles represent target genes and grey circles represent other genes on the PPI network. (A) We overlaid expression profiles to PPI network, and mapped putative disease genes and differentially expressed target genes onto this weighted PPI network. (B) For each disease gene, we found its shortest paths to all target genes. (C) We computed the information flow for each node in a given subnetwork, and genes participating in several subnetworks can have several information scores. (D) We identified modules by assigning a gene to the module in which its information score is maximum.