Inter-module coexpression and intra-module coordination. (A) To analyze coexpression within modules, we computed the average Pearson's correlation coefficient (PCC) of all edges in each module, and compared it with that of 1000 random control edge sets of the same size. (B) Module interaction identification was based on the weighted protein-protein interactions between modules. Edge width corresponds to the absolute value of PCC of two end nodes. Color edges represent cross-module interactions which will be used to compute module interaction, while grey edges are interactions within modules. (C) Intra-module coordination. Node colors range from green to red correspond to significance -log(p-value) of inter-module coexpression, node size corresponds to module size, and edge width corresponds to strength of interactions.