Figure 2

CTCF binding can co-localise with ER and/or FOXA1 in MCF-7 cells. CTCF, ER and FOXA1 binding profiles in MCF-7 cells were analysed. A. Heat map showing clustered binding signal for ER, FOXA1 and CTCF binding in MCF-7 cells. The heat map shows regions co-bound by ER/FOXA1/CTCF, or ER/CTCF or FOXA1/CTCF. The window represents -/+ 5 kb regions from the centre of the CTCF binding events. B. The sum of the normalised binding intensity profile of CTCF, ER and FOXA1 in regions co-bound by all three factors is shown. C. Two examples of genomic loci bound by CTCF, ER and FOXA1 in MCF-7 cells. D. Heat maps showing enriched motifs (the p values are shown) in regions bound by CTCF together with ER and/or FOXA1.