Figure 3

CTCF/ER bound regions are more likely to be near estrogen-regulated genes. Genomic regions bound by ER/FOXA1/CTCF, ER/CTCF, FOXA1/CTCF or regions bound by ER and FOXA1, but not CTCF, were analysed to determine whether they were enriched near estrogen-regulated genes. Genes that are up- or down-regulated by estrogen within six hours of estrogen treatment were included. The percentage of binding events +/- 20 kb from an estrogen up- or down-regulated gene was assessed. Graph showing the percentage of binding events in the different classes that are -/+ 20 kb from estrogen up- or down-regulated genes. Included as a control are binding events that overlap between ER and FOXA1 binding but do not overlap with CTCF binding. ** denotes p < 2.5 × 10^-5