HMM-based identification of S. mansoni and S. mediterranea GPCRs. The transmembrane frequency distribution of the S. mansoni (left) and S. mediterranea (right) predicted proteomes is shown as predicted by HMMTOP at various junctures of the bioinformatics protocol for the Rhodopsin family. The top graphs overlay the HMM-derived sequence pools (black, yellow outline) on top of the entire predicted proteomes (white, black outline) in the assayed TM domain range (3-15). The middle graphs overlay the BLASTp filtered sequence pools (black, yellow outline) on top of the HMM-derived pools (white, black outline). The bottom graphs display the final distributions upon filtering, and after the removal of redundant sequences in the case of S. mediterranea.