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Table 3 Comparison of PROF1 motifs and classical Rhodopsin motifs

From: The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea

Location

Rhodopsin

PROF1-I

PROF1-II

PROF1-III

TM2

LA..D

[L/I][A/S]..[D/E]

[L/I][A/T]..[H/N]

[L/I]A..[D/E]

TM3/IL2

[D/E]R[Y/H]

D[R/K][C/M]

DR[L/V]

D[R/S]C

TM6

[F/Y]...W.P

[F/Y]...[S/A].[P/L]

[F/V]...T.P

S...I.S

TM7

[N/D]P..Y

[N/S][F/G]..[Y/F]

[N/D]F..[Y/F]

N[F/I]..[M/L]

  1. PROF1 motifs are compared to ubiquitous Rhodopsin family motifs. Motifs are displayed as regular expressions. The two most frequently occurring amino acids are shown for each position in order of frequency, except in cases where a particular residue is absolutely conserved or when there is no clear second in frequency rank. Bolded text is used to highlight positional agreement between PROF1 motifs and the corresponding Rhodopsin motifs. More specifically, instances where the most frequently occurring residue is equivalent.