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Table 1 List of differentially expressed genes at least in one time point involved in signalling pathways.

From: Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model

Gene Name Gene Symbol FC (0.25-4d) adj.-p FC (5-8d) adj.-p FC (9-14d) adj.-p
   IGF1-AKT-FOXO signalling    
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) Akt3 1.1 7.7E-01 1.6 1.2E-02 2.5 2.9E-06
insulin-like growth factor 1 receptor Igf1r 1.2 1.2E-01 2.0 2.6E-06 1.8 4.5E-06
insulin-like growth factor 2 mRNA binding protein 2 Igf2bp2 1.1 8.1E-01 2.2 4.8E-05 1.6 2.5E-03
forkhead box O1 Foxo1 3.1 3.1E-04 1.2 6.4E-01 -1.1 7.0E-01
insulin-like growth factor binding protein 6 Igfbp6 -1.2 7.0E-01 -4.6 1.2E-04 -2.5 4.8E-03
insulin receptor substrate 1 Irs1 -1.9 2.9E-02 -4.2 8.4E-06 -3.9 2.4E-06
   NF- k B signalling     
ectodysplasin A2 receptor Eda2r 1.5 6.5E-01 4.7 8.5E-03 4.4 4.1E-03
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon Nfkbie 1.1 8.8E-01 2.1 6.2E-02 3.5 6.8E-04
mitogen-activated protein kinase kinase kinase 14 Map3k14 1.7 4.3E-01 3.5 3.0E-02 3.3 1.7E-02
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 Nfkb2 1.3 6.5E-01 3.6 5.6E-03 3.1 5.5E-03
lipopolysaccharide-induced TNF factor Litaf 1.7 4.1E-03 3.5 1.3E-07 3.0 5.2E-08
mitogen-activated protein kinase kinase kinase kinase 4 Map4k4 1.1 8.5E-01 3.5 9.4E-05 2.5 8.2E-04
Tnf receptor-associated factor 2 Traf2 -1.0 1.0E+00 2.8 2.1E-03 2.4 2.4E-03
interleukin-1 receptor-associated kinase 4 Irak4 1.2 2.2E-01 1.6 1.6E-03 2.2 4.0E-07
activating signal cointegrator 1 complex subunit 2 Ascc2 1.4 1.0E-01 2.4 1.2E-04 2.1 2.8E-04
   TGF-β signalling     
TGFB-induced factor homeobox 1 Tgif1 2.5 1.7E-03 5.7 1.1E-06 5.4 1.7E-07
follistatin Fst 1.0 9.5E-01 1.8 5.5E-02 4.1 3.5E-06
latent transforming growth factor beta binding protein 1 Ltbp1 1.2 8.0E-01 4.2 2.7E-03 4.1 9.9E-04
activin A receptor, type IIB Acvr2b -1.4 3.7E-02 -1.5 3.7E-03 -2.0 2.3E-06
activin A receptor, type I Acvr1 -1.6 6.3E-03 -2.1 2.2E-04 -2.3 5.5E-06
myostatin Mstn 1.8 1.5E-01 -5.6 5.0E-05 -3.7 2.8E-04
   JAK-STAT signalling     
signal transducer and activator of transcription 2 Stat2 1.2 5.4E-01 1.8 5.3E-03 2.4 1.5E-05
jun B proto-oncogene Junb 1.9 1.7E-01 1.7 2.0E-01 2.3 1.9E-02
Janus kinase 2 Jak2 1.4 9.8E-02 1.8 5.1E-03 2.2 6.8E-05
suppressor of cytokine signaling 2 Socs2 -2.6 6.6E-06 -3.5 2.9E-07 -2.1 5.0E-05
cytokine inducible SH2-containing protein Cish -3.7 3.9E-02 -6.2 3.6E-03 -4.6 5.2E-03
   p38 MAPK cascade     
mitogen-activated protein kinase-activated protein kinase 2 Mapkapk2 -1.2 1.4E-01 -1.9 8.2E-06 -2.2 4.4E-08
mitogen-activated protein kinase kinase 6 Map2k6 -2.4 6.7E-02 -9.4 1.6E-05 -7.0 1.6E-05
dual specificity phosphatase 1 Dusp1 -2.0 1.1E-01 -4.9 3.0E-04 -3.8 5.2E-04
dual specificity phosphatase 10 Dusp10 -3.2 7.5E-05 -1.5 1.3E-01 -1.2 4.0E-01
dual specificity phosphatase 14 Dusp14 -1.3 3.2E-01 -2.2 1.9E-03 -1.7 1.5E-02
dual specificity phosphatase 8 Dusp8 -1.9 2.7E-03 -4.5 7.8E-08 -7.1 5.4E-11
   p53 signalling     
tumor protein p53 inducible nuclear protein 1 Tp53inp1 2.6 2.7E-05 4.5 7.7E-08 3.9 1.2E-08
nucleophosmin (nucleolar phosphoprotein B23, numatrin) Npm1 1.4 2.4E-01 2.5 1.7E-04 2.5 5.5E-05
cytoplasmic FMR1 interacting protein 2 Cyfip2 -1.0 9.9E-01 1.1 8.4E-01 2.1 3.2E-05
Bri3 binding protein Bri3bp 1.1 6.2E-01 2.1 1.2E-04 2.1 1.6E-05
homeodomain interacting protein kinase 2 Hipk2 1.1 2.6E-01 2.0 8.7E-08 1.7 4.8E-07
tumor protein p53 inducible nuclear protein 2 Trp53inp2 -1.3 3.6E-01 -2.4 1.1E-03 -2.2 1.1E-03
  1. FC = fold change at the three different time points (0.25-4d, 5-8d, 9-14d) with its corresponding adjusted p-value.