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Table 1 List of differentially expressed genes at least in one time point involved in signalling pathways.

From: Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model

Gene Name

Gene Symbol

FC (0.25-4d)

adj.-p

FC (5-8d)

adj.-p

FC (9-14d)

adj.-p

  

IGF1-AKT-FOXO signalling

   

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

Akt3

1.1

7.7E-01

1.6

1.2E-02

2.5

2.9E-06

insulin-like growth factor 1 receptor

Igf1r

1.2

1.2E-01

2.0

2.6E-06

1.8

4.5E-06

insulin-like growth factor 2 mRNA binding protein 2

Igf2bp2

1.1

8.1E-01

2.2

4.8E-05

1.6

2.5E-03

forkhead box O1

Foxo1

3.1

3.1E-04

1.2

6.4E-01

-1.1

7.0E-01

insulin-like growth factor binding protein 6

Igfbp6

-1.2

7.0E-01

-4.6

1.2E-04

-2.5

4.8E-03

insulin receptor substrate 1

Irs1

-1.9

2.9E-02

-4.2

8.4E-06

-3.9

2.4E-06

  

NF- k B signalling

    

ectodysplasin A2 receptor

Eda2r

1.5

6.5E-01

4.7

8.5E-03

4.4

4.1E-03

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

Nfkbie

1.1

8.8E-01

2.1

6.2E-02

3.5

6.8E-04

mitogen-activated protein kinase kinase kinase 14

Map3k14

1.7

4.3E-01

3.5

3.0E-02

3.3

1.7E-02

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100

Nfkb2

1.3

6.5E-01

3.6

5.6E-03

3.1

5.5E-03

lipopolysaccharide-induced TNF factor

Litaf

1.7

4.1E-03

3.5

1.3E-07

3.0

5.2E-08

mitogen-activated protein kinase kinase kinase kinase 4

Map4k4

1.1

8.5E-01

3.5

9.4E-05

2.5

8.2E-04

Tnf receptor-associated factor 2

Traf2

-1.0

1.0E+00

2.8

2.1E-03

2.4

2.4E-03

interleukin-1 receptor-associated kinase 4

Irak4

1.2

2.2E-01

1.6

1.6E-03

2.2

4.0E-07

activating signal cointegrator 1 complex subunit 2

Ascc2

1.4

1.0E-01

2.4

1.2E-04

2.1

2.8E-04

  

TGF-β signalling

    

TGFB-induced factor homeobox 1

Tgif1

2.5

1.7E-03

5.7

1.1E-06

5.4

1.7E-07

follistatin

Fst

1.0

9.5E-01

1.8

5.5E-02

4.1

3.5E-06

latent transforming growth factor beta binding protein 1

Ltbp1

1.2

8.0E-01

4.2

2.7E-03

4.1

9.9E-04

activin A receptor, type IIB

Acvr2b

-1.4

3.7E-02

-1.5

3.7E-03

-2.0

2.3E-06

activin A receptor, type I

Acvr1

-1.6

6.3E-03

-2.1

2.2E-04

-2.3

5.5E-06

myostatin

Mstn

1.8

1.5E-01

-5.6

5.0E-05

-3.7

2.8E-04

  

JAK-STAT signalling

    

signal transducer and activator of transcription 2

Stat2

1.2

5.4E-01

1.8

5.3E-03

2.4

1.5E-05

jun B proto-oncogene

Junb

1.9

1.7E-01

1.7

2.0E-01

2.3

1.9E-02

Janus kinase 2

Jak2

1.4

9.8E-02

1.8

5.1E-03

2.2

6.8E-05

suppressor of cytokine signaling 2

Socs2

-2.6

6.6E-06

-3.5

2.9E-07

-2.1

5.0E-05

cytokine inducible SH2-containing protein

Cish

-3.7

3.9E-02

-6.2

3.6E-03

-4.6

5.2E-03

  

p38 MAPK cascade

    

mitogen-activated protein kinase-activated protein kinase 2

Mapkapk2

-1.2

1.4E-01

-1.9

8.2E-06

-2.2

4.4E-08

mitogen-activated protein kinase kinase 6

Map2k6

-2.4

6.7E-02

-9.4

1.6E-05

-7.0

1.6E-05

dual specificity phosphatase 1

Dusp1

-2.0

1.1E-01

-4.9

3.0E-04

-3.8

5.2E-04

dual specificity phosphatase 10

Dusp10

-3.2

7.5E-05

-1.5

1.3E-01

-1.2

4.0E-01

dual specificity phosphatase 14

Dusp14

-1.3

3.2E-01

-2.2

1.9E-03

-1.7

1.5E-02

dual specificity phosphatase 8

Dusp8

-1.9

2.7E-03

-4.5

7.8E-08

-7.1

5.4E-11

  

p53 signalling

    

tumor protein p53 inducible nuclear protein 1

Tp53inp1

2.6

2.7E-05

4.5

7.7E-08

3.9

1.2E-08

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Npm1

1.4

2.4E-01

2.5

1.7E-04

2.5

5.5E-05

cytoplasmic FMR1 interacting protein 2

Cyfip2

-1.0

9.9E-01

1.1

8.4E-01

2.1

3.2E-05

Bri3 binding protein

Bri3bp

1.1

6.2E-01

2.1

1.2E-04

2.1

1.6E-05

homeodomain interacting protein kinase 2

Hipk2

1.1

2.6E-01

2.0

8.7E-08

1.7

4.8E-07

tumor protein p53 inducible nuclear protein 2

Trp53inp2

-1.3

3.6E-01

-2.4

1.1E-03

-2.2

1.1E-03

  1. FC = fold change at the three different time points (0.25-4d, 5-8d, 9-14d) with its corresponding adjusted p-value.