From: Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model
Gene Name | Gene Symbol | FC (0.25-4d) | adj.-p | FC (5-8d) | adj.-p | FC (9-14d) | adj.-p |
---|---|---|---|---|---|---|---|
 |  | IGF1-AKT-FOXO signalling |  |  |  | ||
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | Akt3 | 1.1 | 7.7E-01 | 1.6 | 1.2E-02 | 2.5 | 2.9E-06 |
insulin-like growth factor 1 receptor | Igf1r | 1.2 | 1.2E-01 | 2.0 | 2.6E-06 | 1.8 | 4.5E-06 |
insulin-like growth factor 2 mRNA binding protein 2 | Igf2bp2 | 1.1 | 8.1E-01 | 2.2 | 4.8E-05 | 1.6 | 2.5E-03 |
forkhead box O1 | Foxo1 | 3.1 | 3.1E-04 | 1.2 | 6.4E-01 | -1.1 | 7.0E-01 |
insulin-like growth factor binding protein 6 | Igfbp6 | -1.2 | 7.0E-01 | -4.6 | 1.2E-04 | -2.5 | 4.8E-03 |
insulin receptor substrate 1 | Irs1 | -1.9 | 2.9E-02 | -4.2 | 8.4E-06 | -3.9 | 2.4E-06 |
 |  | NF- k B signalling |  |  |  |  | |
ectodysplasin A2 receptor | Eda2r | 1.5 | 6.5E-01 | 4.7 | 8.5E-03 | 4.4 | 4.1E-03 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | Nfkbie | 1.1 | 8.8E-01 | 2.1 | 6.2E-02 | 3.5 | 6.8E-04 |
mitogen-activated protein kinase kinase kinase 14 | Map3k14 | 1.7 | 4.3E-01 | 3.5 | 3.0E-02 | 3.3 | 1.7E-02 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | Nfkb2 | 1.3 | 6.5E-01 | 3.6 | 5.6E-03 | 3.1 | 5.5E-03 |
lipopolysaccharide-induced TNF factor | Litaf | 1.7 | 4.1E-03 | 3.5 | 1.3E-07 | 3.0 | 5.2E-08 |
mitogen-activated protein kinase kinase kinase kinase 4 | Map4k4 | 1.1 | 8.5E-01 | 3.5 | 9.4E-05 | 2.5 | 8.2E-04 |
Tnf receptor-associated factor 2 | Traf2 | -1.0 | 1.0E+00 | 2.8 | 2.1E-03 | 2.4 | 2.4E-03 |
interleukin-1 receptor-associated kinase 4 | Irak4 | 1.2 | 2.2E-01 | 1.6 | 1.6E-03 | 2.2 | 4.0E-07 |
activating signal cointegrator 1 complex subunit 2 | Ascc2 | 1.4 | 1.0E-01 | 2.4 | 1.2E-04 | 2.1 | 2.8E-04 |
 |  | TGF-β signalling |  |  |  |  | |
TGFB-induced factor homeobox 1 | Tgif1 | 2.5 | 1.7E-03 | 5.7 | 1.1E-06 | 5.4 | 1.7E-07 |
follistatin | Fst | 1.0 | 9.5E-01 | 1.8 | 5.5E-02 | 4.1 | 3.5E-06 |
latent transforming growth factor beta binding protein 1 | Ltbp1 | 1.2 | 8.0E-01 | 4.2 | 2.7E-03 | 4.1 | 9.9E-04 |
activin A receptor, type IIB | Acvr2b | -1.4 | 3.7E-02 | -1.5 | 3.7E-03 | -2.0 | 2.3E-06 |
activin A receptor, type I | Acvr1 | -1.6 | 6.3E-03 | -2.1 | 2.2E-04 | -2.3 | 5.5E-06 |
myostatin | Mstn | 1.8 | 1.5E-01 | -5.6 | 5.0E-05 | -3.7 | 2.8E-04 |
 |  | JAK-STAT signalling |  |  |  |  | |
signal transducer and activator of transcription 2 | Stat2 | 1.2 | 5.4E-01 | 1.8 | 5.3E-03 | 2.4 | 1.5E-05 |
jun B proto-oncogene | Junb | 1.9 | 1.7E-01 | 1.7 | 2.0E-01 | 2.3 | 1.9E-02 |
Janus kinase 2 | Jak2 | 1.4 | 9.8E-02 | 1.8 | 5.1E-03 | 2.2 | 6.8E-05 |
suppressor of cytokine signaling 2 | Socs2 | -2.6 | 6.6E-06 | -3.5 | 2.9E-07 | -2.1 | 5.0E-05 |
cytokine inducible SH2-containing protein | Cish | -3.7 | 3.9E-02 | -6.2 | 3.6E-03 | -4.6 | 5.2E-03 |
 |  | p38 MAPK cascade |  |  |  |  | |
mitogen-activated protein kinase-activated protein kinase 2 | Mapkapk2 | -1.2 | 1.4E-01 | -1.9 | 8.2E-06 | -2.2 | 4.4E-08 |
mitogen-activated protein kinase kinase 6 | Map2k6 | -2.4 | 6.7E-02 | -9.4 | 1.6E-05 | -7.0 | 1.6E-05 |
dual specificity phosphatase 1 | Dusp1 | -2.0 | 1.1E-01 | -4.9 | 3.0E-04 | -3.8 | 5.2E-04 |
dual specificity phosphatase 10 | Dusp10 | -3.2 | 7.5E-05 | -1.5 | 1.3E-01 | -1.2 | 4.0E-01 |
dual specificity phosphatase 14 | Dusp14 | -1.3 | 3.2E-01 | -2.2 | 1.9E-03 | -1.7 | 1.5E-02 |
dual specificity phosphatase 8 | Dusp8 | -1.9 | 2.7E-03 | -4.5 | 7.8E-08 | -7.1 | 5.4E-11 |
 |  | p53 signalling |  |  |  |  | |
tumor protein p53 inducible nuclear protein 1 | Tp53inp1 | 2.6 | 2.7E-05 | 4.5 | 7.7E-08 | 3.9 | 1.2E-08 |
nucleophosmin (nucleolar phosphoprotein B23, numatrin) | Npm1 | 1.4 | 2.4E-01 | 2.5 | 1.7E-04 | 2.5 | 5.5E-05 |
cytoplasmic FMR1 interacting protein 2 | Cyfip2 | -1.0 | 9.9E-01 | 1.1 | 8.4E-01 | 2.1 | 3.2E-05 |
Bri3 binding protein | Bri3bp | 1.1 | 6.2E-01 | 2.1 | 1.2E-04 | 2.1 | 1.6E-05 |
homeodomain interacting protein kinase 2 | Hipk2 | 1.1 | 2.6E-01 | 2.0 | 8.7E-08 | 1.7 | 4.8E-07 |
tumor protein p53 inducible nuclear protein 2 | Trp53inp2 | -1.3 | 3.6E-01 | -2.4 | 1.1E-03 | -2.2 | 1.1E-03 |