Paralog segregation buffers dosage imbalance effects and hence scales with dosage sensitivity. Paralog segregation within a gene family is described by expression correlation parameter <η>, while dosage sensitivity is indicated by <ν>, the average underwrapping of gene products in the family. The <η>-<ν> interdependence is normalized by the divergence time of the family, indicated by Ks. Plot of Ks <ν> versus <η> for 1957 human families (A), 1391 fly families (B), 2137 worm families (C) and 1354 yeast families (D) with combined genetic, expression and structural information (Materials and Methods). The correlation coefficient R2 was obtained by regression analysis.