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Table 2 Gene ontology (GO) categories identified using IPA

From: Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes

Gene ontology category P-value range Number of genes
Inflammatory response 1.66 × 10-11 - 1.64 × 10-2 241
Cellular development 8.95 × 10-10 - 1.57 × 10-2 308
Cellular growth and proliferation 1.65 × 10-9 - 1.57 × 10-2 333
Haematological system development and function 1.65 × 10-9 - 1.64 × 10-2 279
Haematopoiesis 2.60 × 10-8 - 1.57 × 10-2 173
Tissue morphology 1.78 × 10-7 - 1.19 × 10-2 114
Cellular function and maintenance 5.44 × 10-7 - 1.65 ×10-2 138
Cell death 9.57 × 10-7 - 1.60 × 10-2 419
Cell-mediated immune response 1.06 × 10-6 - 1.25 × 10-2 109
Connective tissue disorders 1.72 × 10-6 - 5.94 × 10-3 234
Immunological disease 1.72 × 10-6 - 1.57 × 10-2 344
Inflammatory disease 1.72 × 10-6 - 1.28 × 10-2 364
Skeletal and muscular disorders 1.72 × 10-6 - 1.22 × 10-2 235
Infectious disease 1.82 × 10-6 - 1.17 × 10-2 223
Cell-to-cell signalling and interaction 8.33 × 10-6 - 1.64 × 10-2 210
Dermatological diseases and conditions 1.04 × 10-5 - 1.57 × 10-2 107
Free radical scavenging 1.23 × 10-5 - 1.23 × 10-5 14
Molecular transport 1.23 × 10-5 - 7.43 × 10-3 86
Cell signalling 2.40 × 10-5 - 7.21 × 10-5 133
Respiratory disease 2.86 × 10-5 - 1.24 × 10-2 109
Cellular compromise 3.09 × 10-5 - 1.57 × 10-2 41
Genetic disorder 3.39 × 10-5 - 1.64 × 10-2 104
Immune cell trafficking 3.51 × 10-5 - 1.64 × 10-2 163
Humoral immune response 5.08 × 10-5 - 1.19 × 10-2 78
Organismal injury and abnormalities 9.51 × 10-5 - 1.05 × 10-2 81
Tissue development 1.19 × 10-4 - 1.05 × 10-2 108
Haematological disease 1.78 × 10-4 - 1.35 × 10-2 162
Gastrointestinal disease 1.88 × 10-4 - 5.51 × 10-3 42
Hepatic system disease 1.88 × 10-4 - 1.64 × 10-2 89
Lymphoid tissue structure and development 1.94 × 10-4 - 5.94 × 10-3 5
Antigen presentation 3.42 × 10-4 -1.64 × 10-2 83
Cellular movement 3.58 × 10-4 - 1.63 × 10-2 157
Vitamin and mineral metabolism 3.59 × 10-4 - 7.21 × 10-3 74
Antimicrobial response 3.92 × 10-4 - 1.28 × 10-2 32
Hypersensitivity response 5.86 × 10-4 - 8.60 × 10-3 31
Infection mechanism 9.89 × 10-4 - 1.57 × 10-2 39
Gene expression 1.07 × 10-3 - 1.57 × 10-2 254
Hair and skin development and function 1.23 × 10-3 - 1.57 × 10-2 22
Post-translational modification 2.27 × 10-3 - 9.78 × 10-3 84
Cancer 2.51 × 10-3 - 1.57 × 10-2 385
Endocrine system development and function 2.65 × 10-3 - 2.65 × 10-3 21
Carbohydrate metabolism 3.77 × 10-3 - 3.77 × 10-3 6
Cell morphology 3.77 × 10-3 - 1.28 × 10-2 23
Lipid metabolism 3.77 × 10-3 - 7.43 × 10-3 17
Neurological disease 3.77 × 10-3 - 1.47 × 10-2 49
Small molecule biochemistry 3.77 × 10-3 - 7.43 × 10-3 23
Metabolic disease 3.91 × 10-3 - 3.91 × 10-3 7
Embryonic development 4.59 × 10-3 - 1.57 × 10-2 21
Nervous system development and function 4.59 × 10-5 - 1.18 × 10-2 8
Reproductive system disease 5.84 × 10-3 - 7.54 × 10-3 79
Cell cycle 5.94 × 10-3 - 1.18 × 10-2 20
Endocrine system disorders 5.94 × 10-3 - 5.94 × 10-3 3
Opthalmic disease 5.94 × 10-3 - 6.60 × 10-3 7
RNA post-transcriptional modification 6.04 × 10-3 - 6.04 × 10-3 13
Cardiovascular system development and function 6.68 × 10-3 - 1.30 ×10-2 19
Cell assembly and modification 6.68 × 10-3 - 1.28 × 10-2 14
Organ development 6.68 × 10-3 - 1.19 × 10-2 6
Renal and urological system development and function 1.18 × 10-2 - 1.30 × 10-2 11
Reproductive system development and function 1.18 × 10-2 - 1.18 × 10-2 4
  1. The top ranking GO categories identified by IPA are listed according to P-values. P-value ranges are based on subcategory P-values within each parent term.