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Table 3 Top-ranking canonical pathways identified using IPA

From: Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes

Canonical Pathway Name

P-value

Ratio

Natural killer cell signalling

3.06 × 10-4

23/112 (0.205)

Communication between innate and adaptive immune cells

4.11 × 10-4

17/89 (0.191)

TREM1 signalling

2.20 × 10-3

15/69 (0.217)

Dendritic cell maturation

4.96 × 10-3

29/174 (0.167)

Cysteine metabolism

7.43 × 10-3

9/90 (0.100)

JAK/STAT signalling

8.22 × 10-3

15/64 (0.234)

NRF2-mediated oxidative stress response

8.98 × 10-3

35/183 (0.191)

T cell receptor signalling

1.08 × 10-2

20/107 (0.187)

IL6 signalling

1.52 × 10-2

20/93 (0.215)

CCR5 signalling in macrophages

1.84 × 10-2

16/92 (0.174)

Chemokine signalling

1.92 × 10-2

15/75 (0.200)

Calcium-induced T-lymphocyte apoptosis

2.07 × 10-2

12/66 (0.182)

IL-17 signalling

2.21 × 10-2

16/74 (0.216)

Prolactin signalling

2.21 × 10-2

16/75 (0.213)

Synaptic long term potentiation

2.22 × 10-2

19/113 (0.168)

Toll-like receptor signalling

2.63 × 10-2

11/54 (0.204)

FLT3 signalling in hematopoietic progenitor cells

2.77 × 10-2

15/74 (0.203)

Systemic lupus erythematosus signalling

2.81 × 10-2

20/151 (0.132)

Renin angiotensin signalling

3.01 × 10-2

21/120 (0.175)

Phospholipase C signalling

3.28 × 10-2

39/253 (0.154)

Oncostatin M signalling

3.36 × 10-2

9/35 (0.257)

Thyroid cancer signalling

3.36 × 10-2

9/42 (0.214)

B cell receptor signalling

3.72 × 10-2

25/154 (0.162)

Interferon signalling

3.97 × 10-2

6/30 (0.200)

Production of nitric oxide and reactive oxygen species in macrophages

4.13 × 10-2

28/185 (0.151)

NF-κB signalling

4.17 × 10-2

25/152 (0.164)

Notch signalling

4.29 × 10-2

8/43 (0.186)

IL10 signalling

4.36 × 10-2

13/70 (0.186)

P38 MAPK signalling

4.57 × 10-2

17/97 (0.175)

Role of NFAT in regulation of the immune response

4.70 × 10-2

29/196 (0.148)

Parkinson's signalling

5.00 × 10-2

5/17 (0.294)

  1. The top ranking canonical pathways identified by IPA are listed according to P-values. The ratio indicates the number of differentially expressed genes involved in each canonical pathway divided by the total number of genes within each pathway as per the IPA Knowledge Base.