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Table 3 Top-ranking canonical pathways identified using IPA

From: Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes

Canonical Pathway Name P-value Ratio
Natural killer cell signalling 3.06 × 10-4 23/112 (0.205)
Communication between innate and adaptive immune cells 4.11 × 10-4 17/89 (0.191)
TREM1 signalling 2.20 × 10-3 15/69 (0.217)
Dendritic cell maturation 4.96 × 10-3 29/174 (0.167)
Cysteine metabolism 7.43 × 10-3 9/90 (0.100)
JAK/STAT signalling 8.22 × 10-3 15/64 (0.234)
NRF2-mediated oxidative stress response 8.98 × 10-3 35/183 (0.191)
T cell receptor signalling 1.08 × 10-2 20/107 (0.187)
IL6 signalling 1.52 × 10-2 20/93 (0.215)
CCR5 signalling in macrophages 1.84 × 10-2 16/92 (0.174)
Chemokine signalling 1.92 × 10-2 15/75 (0.200)
Calcium-induced T-lymphocyte apoptosis 2.07 × 10-2 12/66 (0.182)
IL-17 signalling 2.21 × 10-2 16/74 (0.216)
Prolactin signalling 2.21 × 10-2 16/75 (0.213)
Synaptic long term potentiation 2.22 × 10-2 19/113 (0.168)
Toll-like receptor signalling 2.63 × 10-2 11/54 (0.204)
FLT3 signalling in hematopoietic progenitor cells 2.77 × 10-2 15/74 (0.203)
Systemic lupus erythematosus signalling 2.81 × 10-2 20/151 (0.132)
Renin angiotensin signalling 3.01 × 10-2 21/120 (0.175)
Phospholipase C signalling 3.28 × 10-2 39/253 (0.154)
Oncostatin M signalling 3.36 × 10-2 9/35 (0.257)
Thyroid cancer signalling 3.36 × 10-2 9/42 (0.214)
B cell receptor signalling 3.72 × 10-2 25/154 (0.162)
Interferon signalling 3.97 × 10-2 6/30 (0.200)
Production of nitric oxide and reactive oxygen species in macrophages 4.13 × 10-2 28/185 (0.151)
NF-κB signalling 4.17 × 10-2 25/152 (0.164)
Notch signalling 4.29 × 10-2 8/43 (0.186)
IL10 signalling 4.36 × 10-2 13/70 (0.186)
P38 MAPK signalling 4.57 × 10-2 17/97 (0.175)
Role of NFAT in regulation of the immune response 4.70 × 10-2 29/196 (0.148)
Parkinson's signalling 5.00 × 10-2 5/17 (0.294)
  1. The top ranking canonical pathways identified by IPA are listed according to P-values. The ratio indicates the number of differentially expressed genes involved in each canonical pathway divided by the total number of genes within each pathway as per the IPA Knowledge Base.