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Table 1 Basic information on PCSK genes and whole genome expression correlations

From: Identification of proprotein convertase substrates using genome-wide expression correlation analysis

    

Top 5% (n = 861/867)

Bottom 5% (n = 861/867)

 

gene

id

# correlating genes in GeneSapiens (5%)

# of common samples with other genes

# genes with furin/general PC cleavage site and signal peptide

max/min correlation

# genes with furin/general PC cleavage site and signal peptide

max/min correlation

p value*

PCSK1

ensg00000175426

17330 (867)

445-1698

160

0.810/0.450

102

-0.246/-0.479

1.24E-4

PCSK2

ensg00000125851

17330 (867)

445-1698

170

0.871/0.541

96

-0.334/-0.637

5.10E-7

FURIN

ensg00000140564

17330 (867)

445-1698

161

0.652/0.332

83

-0.253/-0.512

4.21E-9/2.10E-7

PCSK4

ensg00000115257

17215 (861)

497-668

104

0.592/0.300

67

-0.236/-0.480

2.25E-4

PCSK5

ensg00000099139

17330 (867)

445-1698

116

0.636/0.232

158

-0.245/-0.493

4.45E-3

PCSK6

ensg00000140479

17330 (867)

445-1698

165

0.833/0.302

60

-0.277/-0.526

< 1E-10

PCSK7

ensg00000160613

17330 (867)

445-1698

111

0.571/0.312

109

-0.236/-0.481

0.71

  1. Genes with PCSK cleavage site and signal peptide accumulate in top 5% correlating genes
  2. * Chi-square test for top 5% vs bottom 5% correlating genes/fraction of genes with PCSK detection site and signal peptide from all 5% genes.