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Table 1 Changes in protein expression following cold-adaptation as determined by LC/MS-based label-free protein quantitative analysis.

From: Proteomic analysis of endothelial cold-adaptation

Protein priority Peptide ID confidence Multiple sequences Number of proteins Number significant changes Maximum absolute fold change Number increasing at 25°C Number decreasing at 25°C
1 High Yes 440 169 (15.5%) 1.70 73 96
2 High No 364 50 (4.6%) 1.92 12 38
3 Moderate Yes 7 4 (0.04%) 1.23 0 4
4 Moderate No 278 81 (7.4%) 2.37 17 64
Overall    1089 304 (27.9%) 2.37 102 (9.4%) 202 (18.5%)
  1. A total of 1089 proteins were identified by LC/MS and 27.9% of these had significantly increased or decreased in abundance following 25°C/72 h. Priorities 1-4 were assigned based on confidence in peptide identification (High and Moderate) and whether or not there are multiple amino acid sequences (Yes or No) identified. Please see references [24] and [26] for more details about how the protein priority is determined.