Figure 3
From: Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancers
Pbx-hox motifs in CNEs strongly resemble verified PBX-HOX binding-sites. Position frequency logos generated from Gnathostome alignments (based on 712 conserved human TGATNNAT motifs in 4529 CNE alignments), Human CNEs (generated from the CONDOR CNE set using Cis-finder [41]) and from previous studies [36] (Literature). The relative base frequencies at positions 5 and 6, and 9 and 10, in CNEs, are in good agreement with known functional Pbx-Hox binding sites, supporting a strong KR consensus.