Skip to main content

Table 1 GSEA tests for GO classes enriched following acute treatment

From: Gene set enrichment analysis of microarray data from Pimephales promelas (Rafinesque), a non-mammalian model organism

GO term

GO definition

Size

ES

NES

NOM p-value

UP-regulated in treatment:

   

GO:0042254

Ribosome biogenesis and assembly

14

0.708

1.591

0.000

GO:0006364

rRNA processing

11

0.717

1.510

0.000

GO:0015031

Protein transport

122

0.437

1.614

0.014

GO:0006754

ATP biosynthesis

56

0.438

1.360

0.014

GO:0006486

Protein amino acid glycosylation

75

0.378

1.280

0.133

GO:0006605

Protein targeting

85

0.436

1.557

0.013

GO:0009058

Biosynthesis

327

0.324

1.315

0.149

GO:0045045

Secretory pathway

59

0.422

1.448

0.064

GO:0007046

Ribosome biogenesis

94

0.552

1.553

0.054

GO:0006457

Protein folding

44

0.466

1.387

0.086

GO:0006633

Fatty acid biosynthesis

11

0.411

1.162

0.296

GO:0006888

ER to golgi vesicle mediated transport

11

0.365

0.864

0.676

DOWN-regulated in treatment:

   

GO:0009165

Nucleotide biosynthesis

12

-0.379

-1.047

0.458

GO:0007498

Mesoderm development

10

-0.647

-1.610

0.000

  1. Results for gene sets representing each GO-BP class identified by Klaper et al. [12, 13], tested for enrichment by GSEA following acute methylmercury treatment. GO terms and definitions can be used to retrieve each set (and constituent genes) from MSigDB [8]; size refers to the number of genes in the set; ES and NES are the enrichment scores and normalized enrichment scores (respectively) for the set; NOM p-value is the nominal p-value for the NES. Gene sets representing GO-BP classes with statistically significant normalized enrichment scores are highlighted in bold.