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Table 1 GSEA tests for GO classes enriched following acute treatment

From: Gene set enrichment analysis of microarray data from Pimephales promelas (Rafinesque), a non-mammalian model organism

GO term GO definition Size ES NES NOM p-value
UP-regulated in treatment:    
GO:0042254 Ribosome biogenesis and assembly 14 0.708 1.591 0.000
GO:0006364 rRNA processing 11 0.717 1.510 0.000
GO:0015031 Protein transport 122 0.437 1.614 0.014
GO:0006754 ATP biosynthesis 56 0.438 1.360 0.014
GO:0006486 Protein amino acid glycosylation 75 0.378 1.280 0.133
GO:0006605 Protein targeting 85 0.436 1.557 0.013
GO:0009058 Biosynthesis 327 0.324 1.315 0.149
GO:0045045 Secretory pathway 59 0.422 1.448 0.064
GO:0007046 Ribosome biogenesis 94 0.552 1.553 0.054
GO:0006457 Protein folding 44 0.466 1.387 0.086
GO:0006633 Fatty acid biosynthesis 11 0.411 1.162 0.296
GO:0006888 ER to golgi vesicle mediated transport 11 0.365 0.864 0.676
DOWN-regulated in treatment:    
GO:0009165 Nucleotide biosynthesis 12 -0.379 -1.047 0.458
GO:0007498 Mesoderm development 10 -0.647 -1.610 0.000
  1. Results for gene sets representing each GO-BP class identified by Klaper et al. [12, 13], tested for enrichment by GSEA following acute methylmercury treatment. GO terms and definitions can be used to retrieve each set (and constituent genes) from MSigDB [8]; size refers to the number of genes in the set; ES and NES are the enrichment scores and normalized enrichment scores (respectively) for the set; NOM p-value is the nominal p-value for the NES. Gene sets representing GO-BP classes with statistically significant normalized enrichment scores are highlighted in bold.