Gene set enrichment analysis of microarray data from Pimephales promelas (Rafinesque), a non-mammalian model organism

Table 2 GSEA tests for GO classes enriched following chronic treatment

GO term	GO definition	Size	ES	NES	NOM p-value
UP-regulated in treatment:
GO:0006605	Protein targeting	85	0.387	1.416	0.054
GO:0016485	Protein processing	32	0.413	1.267	0.086
GO:0006897	Endocytosis	162	0.253	1.091	0.278
GO:0000226	Microtubule cytoskeleton organization and biogenesis	28	0.376	1.004	0.484
GO:0007409	Axonogenesis	29	0.362	0.992	0.614
GO:0045893	Positive regulation of transcription, DNA dependent	270	0.200	0.898	0.502
GO:0006887	Exocytosis	15	0.402	0.856	0.763
GO:0006289	Nucleotide-excision repair	14	0.287	0.842	0.806
GO:0007269	Neurotransmitter secretion	10	0.302	0.702	0.786
DOWN-regulated in treatment:
GO:0006917	Induction of apoptosis	208	-0.286	-1.093	0.396
GO:0009615	Response to virus	21	-0.301	-1.198	0.130
GO:0001756	Somitogenesis	17	-0.356	-1.020	0.502

Results for each GO-BP class identified by Klaper et al. [12, 13], tested for enrichment by GSEA following chronic methylmercury treatment. Size refers to the number of genes in the set; ES and NES are the enrichment scores and normalized enrichment scores (respectively) for the set; NOM p-value is the nominal p-value for the NES.

ISSN: 1471-2164