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Table 2 GSEA tests for GO classes enriched following chronic treatment

From: Gene set enrichment analysis of microarray data from Pimephales promelas (Rafinesque), a non-mammalian model organism

GO term GO definition Size ES NES NOM p-value
UP-regulated in treatment:    
GO:0006605 Protein targeting 85 0.387 1.416 0.054
GO:0016485 Protein processing 32 0.413 1.267 0.086
GO:0006897 Endocytosis 162 0.253 1.091 0.278
GO:0000226 Microtubule cytoskeleton organization and biogenesis 28 0.376 1.004 0.484
GO:0007409 Axonogenesis 29 0.362 0.992 0.614
GO:0045893 Positive regulation of transcription, DNA dependent 270 0.200 0.898 0.502
GO:0006887 Exocytosis 15 0.402 0.856 0.763
GO:0006289 Nucleotide-excision repair 14 0.287 0.842 0.806
GO:0007269 Neurotransmitter secretion 10 0.302 0.702 0.786
DOWN-regulated in treatment:    
GO:0006917 Induction of apoptosis 208 -0.286 -1.093 0.396
GO:0009615 Response to virus 21 -0.301 -1.198 0.130
GO:0001756 Somitogenesis 17 -0.356 -1.020 0.502
  1. Results for each GO-BP class identified by Klaper et al. [12, 13], tested for enrichment by GSEA following chronic methylmercury treatment. Size refers to the number of genes in the set; ES and NES are the enrichment scores and normalized enrichment scores (respectively) for the set; NOM p-value is the nominal p-value for the NES.
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