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Table 4 GSEA tests for enrichment of HCC- and hepatitis-associated gene sets

From: Gene set enrichment analysis of microarray data from Pimephales promelas (Rafinesque), a non-mammalian model organism

Gene Set Name Size ES NES NOM p-value
Up-regulated in acute liver treatment
KUROKAWA_5FU_IFN_SENSITIVE_VS_RESISTANT_DN 25 0.585 1.642 0.025
WONG_IFNA_HCC_RESISTANT_VS_SENSITIVE_UP 10 0.507 1.407 0.046
Down-regulated in acute liver treatment
HBX_HEP_UP 12 -0.540 -1.460 0.038
Up-regulated in chronic liver treatment
HCC_SURVIVAL_GOOD_VS_POOR_DN 112 0.452 1.549 0.000
Down-regulated in chronic liver treatment
None     
  1. Results for gene sets representing Hepatocellular carcinoma (HCC) and hepatitis, tested for enrichment by GSEA following methylmercury treatment. Here, we test whether liver-associated sets are enriched following methylmercury exposure. Size refers to the number of genes in the set; ES and NES are the enrichment scores and normalized enrichment scores (respectively) for the set; NOM p-value is the nominal p-value for the NES. Descriptions of each set (and lists of constituent genes) can be found by searching for set names at the MSigDB [8].