TY - JOUR AU - Liu, Hongde AU - Duan, Xueye AU - Yu, Shuangxin AU - Sun, Xiao PY - 2011 DA - 2011/01/27 TI - Analysis of nucleosome positioning determined by DNA helix curvature in the human genome JO - BMC Genomics SP - 72 VL - 12 IS - 1 AB - Nucleosome positioning has an important role in gene regulation. However, dynamic positioning in vivo casts doubt on the reliability of predictions based on DNA sequence characteristics. What role does sequence-dependent positioning play? In this paper, using a curvature profile model, nucleosomes are predicted in the human genome and patterns of nucleosomes near some key sites are investigated. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-12-72 DO - 10.1186/1471-2164-12-72 ID - Liu2011 ER -