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Table 1 Summary of discovery and replication results

From: A unified framework for multi-locus association analysis of both common and rare variants

Model Size Discovery P-value OR (95% CI) Replication P-value OR (95% CI) rsid Chr Position (bp) Minor/major allele Gene
Dominant 1 8.17 × 10-6 0.65 (0.54, 0.79) 0.845 1.04 (0.69, 1.56) rs1584586 3 151677041 A/G TSC22D2
Dominant 1 6.70 × 10-6 1.71 (1.35, 2.18) 0.037 1.69 (1.02, 2.81) rs1564282 4 842313 T/C GAK
Dominant 1 4.03 × 10-6 1.73 (1.36, 2.21) NA NA rs11248051 4 848332 T/C GAK
Dominant 1 8.25 × 10-6 1.67 (1.32, 2.11) 0.033 1.66 (1.02, 2.71) rs11248060 4 954359 T/C GAK
Dominant 1 1.89 × 10-6 12.95 (3.24, 112.76) NA NA rs7848576 9 697463 G/A ANKRD15
Dominant 1 3.37 × 10-6 0.64 (0.53, 0.78) 0.560 0.89 (0.60, 1.33) rs898528 17 74678398 T/C NA
Dominant 1 6.84 × 10-6 0.65 (0.54, 0.79) 0.283 1.25 (0.84, 1.87) rs2830713 21 27416311 T/C NA
Dominant 2 1.77 × 10-6 1.58 (1.30, 1.91) 0.202 1.30 (0.87, 1.95) rs1564282 4 842313 T/C GAK
       rs2061846 4 842484 C/T GAK
Dominant 2 2.24 × 10-6 1.57 (1.30, 1.90) NA NA rs4690339 4 844712 G/A GAK
       rs11248051 4 848332 T/C GAK
Dominant 2 2.91 × 10-6 0.63 (0.52, 0.77) 0.252 1.28 (0.84, 1.97) rs194907 6 82485214 G/A FAM46A
       rs1276888 6 82489107 T/C FAM46A
Dominant 3 1.40 × 10-6 1.58 (1.31, 1.92) NA NA rs1564282 4 842313 T/C GAK
       rs2061846 4 842484 C/T GAK
       rs4690339 4 844712 G/A GAK
Dominant 3 9.55 × 10-6 0.62 (0.50, 0.77) 1.000 1.01 (0.65, 1.58) rs1881747 10 54003581 C/T NA
       rs1919764 10 54015996 C/T NA
       rs1919738 10 54021111 A/G NA
Dominant 4 5.06 × 10-6 0.61 (0.49, 0.76) 0.914 0.98 (0.63, 1.54) rs7085224 10 53971746 G/A NA
       rs1881747 10 54003581 C/T NA
       rs1919764 10 54015996 C/T NA
       rs1919738 10 54021111 A/G NA
Recessive 1 7.25 × 10-6 0.22 (0.09, 0.46) 0.060 3.72 (0.88, 22.09) rs9310784 3 25905208 C/T NGLY1
Recessive 1 2.26 × 10-6 1.65 (1.33, 2.04) 0.182 0.73 (0.45, 1.16) rs2382722 16 27300127 G/A IL4R, IL21R
Recessive 1 5.36 × 10-6 0.56 (0.43, 0.72) 0.078 1.65 (0.94, 2.91) rs1159220 22 31410753 T/C SYN3
Recessive 1 6.14 × 10-6 0.56 (0.43, 0.73) 0.078 1.65 (0.94, 2.91) rs3788483 22 31414345 C/T SYN3
Recessive 2 8.33 × 10-6 2.06 (1.48, 2.90) 0.521 1.26 (0.64, 2.48) rs2189387 17 36293632 A/G KRT20
       rs7212483 17 36294578 T/C KRT20
Recessive 2 7.75 × 10-6 0.57 (0.44, 0.74) 0.164 1.45 (0.86, 2.45) rs1159220 22 31410753 T/C SYN3
       rs5998577 22 31412043 A/G SYN3