Table 1 Summary of discovery and replication results

Dominant

1

8.17 × 10^-6

0.65 (0.54, 0.79)

0.845

1.04 (0.69, 1.56)

rs1584586

3

151677041

A/G

TSC22D2

Dominant

1

6.70 × 10^-6

1.71 (1.35, 2.18)

0.037

1.69 (1.02, 2.81)

rs1564282

4

842313

T/C

GAK

Dominant

1

4.03 × 10^-6

1.73 (1.36, 2.21)

NA

NA

rs11248051

4

848332

T/C

GAK

Dominant

1

8.25 × 10^-6

1.67 (1.32, 2.11)

0.033

1.66 (1.02, 2.71)

rs11248060

4

954359

T/C

GAK

Dominant

1

1.89 × 10^-6

12.95 (3.24, 112.76)

NA

NA

rs7848576

9

697463

G/A

ANKRD15

Dominant

1

3.37 × 10^-6

0.64 (0.53, 0.78)

0.560

0.89 (0.60, 1.33)

rs898528

17

74678398

T/C

NA

Dominant

1

6.84 × 10^-6

0.65 (0.54, 0.79)

0.283

1.25 (0.84, 1.87)

rs2830713

21

27416311

T/C

NA

Dominant

2

1.77 × 10^-6

1.58 (1.30, 1.91)

0.202

1.30 (0.87, 1.95)

rs1564282

4

842313

T/C

GAK

rs2061846

4

842484

C/T

GAK

Dominant

2

2.24 × 10^-6

1.57 (1.30, 1.90)

NA

NA

rs4690339

4

844712

G/A

GAK

rs11248051

4

848332

T/C

GAK

Dominant

2

2.91 × 10^-6

0.63 (0.52, 0.77)

0.252

1.28 (0.84, 1.97)

rs194907

6

82485214

G/A

FAM46A

rs1276888

6

82489107

T/C

FAM46A

Dominant

3

1.40 × 10^-6

1.58 (1.31, 1.92)

NA

NA

rs1564282

4

842313

T/C

GAK

rs2061846

4

842484

C/T

GAK

rs4690339

4

844712

G/A

GAK

Dominant

3

9.55 × 10^-6

0.62 (0.50, 0.77)

1.000

1.01 (0.65, 1.58)

rs1881747

10

54003581

C/T

NA

rs1919764

10

54015996

C/T

NA

rs1919738

10

54021111

A/G

NA

Dominant

4

5.06 × 10^-6

0.61 (0.49, 0.76)

0.914

0.98 (0.63, 1.54)

rs7085224

10

53971746

G/A

NA

rs1881747

10

54003581

C/T

NA

rs1919764

10

54015996

C/T

NA

rs1919738

10

54021111

A/G

NA

Recessive

1

7.25 × 10^-6

0.22 (0.09, 0.46)

0.060

3.72 (0.88, 22.09)

rs9310784

3

25905208

C/T

NGLY1

Recessive

1

2.26 × 10^-6

1.65 (1.33, 2.04)

0.182

0.73 (0.45, 1.16)

rs2382722

16

27300127

G/A

IL4R, IL21R

Recessive

1

5.36 × 10^-6

0.56 (0.43, 0.72)

0.078

1.65 (0.94, 2.91)

rs1159220

22

31410753

T/C

SYN3

Recessive

1

6.14 × 10^-6

0.56 (0.43, 0.73)

0.078

1.65 (0.94, 2.91)

rs3788483

22

31414345

C/T

SYN3

Recessive

2

8.33 × 10^-6

2.06 (1.48, 2.90)

0.521

1.26 (0.64, 2.48)

rs2189387

17

36293632

A/G

KRT20

rs7212483

17

36294578

T/C

KRT20

Recessive

2

7.75 × 10^-6

0.57 (0.44, 0.74)

0.164

1.45 (0.86, 2.45)

rs1159220

22

31410753

T/C

SYN3

rs5998577

22

31412043

A/G

SYN3