Figure 3
From: Exome localization of complex disease association signals
Combined enrichment of association signal around the gene for seven diseases genotyped by the WTCCC after removal of the MHC region. The percentage of SNPs with p < α (red circles) is plotted for their distance to the closest gene. Values have been smoothed using a 50 kb sliding window (blue line). The light blue area represents the distribution expected by chance (95% confidence intervals) based on 100,000 permutations of the case/control status. The MHC region was defined as chromosome 6, position 25,930,839 to 33,297,046. The purple triangle represents the proportion of SNPs with p < α in coding exons.