Table 3 Top three pathways for overrepresentation in each tissue

Biosynthesis of steroids

3.50E-07

5.80E-05

↑Dhcr7, ↑Fdft1,↑Hmgcr,↑Idi1, ↑Lss, ↑Mvd, ↑Sqle

LXR/RXR Activation

1.57E-04

1.30E-02

↓Abcg5, ↓Abcg8, ↑Acaca, ↑Cyp7a1, ↓Hadh, ↑Hmgcr, ↓Lcat

Pentose/Phosphate Pathway

3.01E-04

1.67E-02

↑Aldoc, ↑G6pd, ↑Gpi, ↓H6pd, ↓Pgm5

Duodenum

Pathway

Biosynthesis of steroids

1.13E-10

1.74E-08

↑Dhcr7, ↑Fdft1, ↑Fntb, ↑Hmgcr, ↑Idi1, ↑Lss, ↑Mvd, ↑Sc5dl, ↑Sqle

Androgen and estrogen metabolism

1.35E-04

1.04E-02

↑Ftsj1, ↑Hsd11b1, ↑Hsd17b7, ↑Nsdhl, ↓Srd5a2, ↓Ugt2b7

Glycerolipid metabolism

1.46E-03

7.50E-02

↓Cel, ↓Clps, ↓Glb1l2, ↓Pnlip, ↓Pnliprp1, ↓Pnliprp2

Jejunum

Pathway

T-Cell receptor signaling

1.68E-07

2.78E-05

↓Bmx, ↓Cd8b, ↓Grap2, ↓Itk, ↓Malt1, ↓Pik3cg, ↓Pik3r1, ↓Ppp3cc, ↓Prkcq, ↓Ptprc, ↓Rasgrp1, ↓Trb

CD28 signaling in T helper cells

1.17E-05

6.74E-04

↓Grap2, ↓Itk, ↓Malt1, ↑Mapk9, ↓Pik3cg, ↓Pik3r1, ↓Ppp3cc, ↓Prkcq, ↓Ptprc, ↓Trb

TR/RXR activation

1.23E-05

6.74E-04

↑Fga, ↑Gh1, ↓Klf9, ↑Ldlr, ↓Pik3cg, ↓Pik3r1, ↓Thra, ↓Thrb, ↓Thrsp

Ileum

Pathway

Biosynthesis of steroids

9.42E-08

1.71E-05

↑Cyp24a1, ↑Dhcr7, ↑Fdft1, ↑Hmgcr, ↑Idi1, ↑Mvd, ↑Sc5dl, ↑Sqle

TR/RXR activation

3.16E-07

2.86E-05

↑Fga, ↑Gh1, ↓Klf9, ↑Me1, ↓Nfcor2, ↓Pck1, ↓Pik3c2b, ↓Pik3cg, ↓Pik3r5, ↓Ppargc1a, ↓Thra, ↓Thrb

Thrombopoietin signaling

4.85E-05

2.53E-03

↓Irs2, ↓Pik3c2b, ↓Pik3cg, ↓Pik3r5, ↓Plcg1, ↓Plcg2, ↓Prkce, ↓Prkcq