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Table 3 Differential expression between the Lean and Fat mice in liver genes

From: Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle

Gene name Gene Symbol GeneBank Code Log2 ratio* L:F**
Cholesterol metabolism     
Mevalonate kinase Mvk NM_023556 0.11
NAD(P) dependent steroid dehydrogenase-like Nsdhl BC019945 0.15
Sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) Sc5d BC024132 0.27
Mevalonate (diphospho) decarboxylase Mvd NM_138656 0.29
Lanosterol synthase Lss NM_146006 0.33
Farnesyl diphosphate synthetase Fdps NM_134469 0.41
Farnesyl diphosphate farnesyl transferase 1 Fdft1 NM_010191 0.44
Acyl-CoA synthetase short-chain family member 2 Acss2 NM_019811 0.36
Bile acid and glucose metabolism    
Glucose-6-phosphatase, catalytic G6Pc NM_008061 -1.01
Pyruvate dehydrogenase (lipoamide) beta Pdhb NM_024221 -0.28
Solute carrier organic anion transporter family, member 1a4 Slco1a4 NM_030687 -0.71
Solute carrier organic anion transporter family, member 1a1 Slco1a1 AY195868 -0.49
Solute carrier organic anion transporter family, member 1b2 Slco1b2 NM_020495 -0.36
Solute carrier family 10 (sodium/bile acid cotransporter family), member 1 Slc10a1 BC094023 -0.13
ATP-binding cassette, sub-family G (WHITE), member 5 Abcg5 NM_031884 -0.15  
ATP-binding cassette, sub-family B (MDR/TAP), member 11 Abcb11 NM_021022 0.65
Cytochrome P450, family 8, subfamily b, polypeptide 1 Cyp8b1 NM_010012 0.52
Drug metabolism     
Cytochrome P450, family 2, subfamily a, polypeptide 5 Cyp2a5 BC011233 -0.52
Cytochrome P450, family 2, subfamily b, polypeptide 10 Cyp2b10 AK028103 -0.44
Cytochrome P450, family 2, subfamily b, polypeptide 9 Cyp2b9 NM_010000 -0.38
Cytochrome P450, family 2, subfamily b, polypeptide 9 Cyp2b9 NM_007813 -0.38
Cytochrome P450, family 3, subfamily a, polypeptide 41A Cyp3a41a NM_017396 -0.37
Cytochrome P450, family 2, subfamily c, polypeptide 69 Cyp2c69 NM_010004 0.34
Cytochrome P450, family 1, subfamily a, polypeptide 2 Cyp1a2 NM_009993 0.41
Complement component 9 C9 BC011137 -1.37
Serum amyloid P-component Apcs BC061125 0.46
Complement component 4B (Childo blood group) C4b BC067409 1.55
C-reactive protein, pentraxin-related Crp NM_007768 0.25
Orosomucoid 1 Orm1 BC012725 -0.34
Hemopexin Hpxn BC019901 0.12
Nuclear receptor subfamily 5, group A, member 2 (LRH-1) Nr5a2 NM_030676 0.16
Acetyl-Coenzyme A acetyltransferase 2 Acat2 NM_009338 0.22
Apolipoprotein A-II Apoa2 BC031786 0.23
Lysosomal acid lipase A Lip1 NM_021460 0.23
Low density lipoprotein receptor Ldlr BC019207 0.27
Insulin induced gene 1 Insig1 NM_153526 0.33
Nitric oxide synthase 1, neuronal Nos1 BC066101 0.34
Adiponectin receptor 2 Adipor2 NM_197985 0.35
  1. * Data represent log2 ratios of Lean (L) versus Fat (F) line (p < 0.05).
  2. **Up arrow indicates increased mRNA expression of particular gene in the Lean (L) line and down arrow decreased expression in the Lean line.