Table 3 Differential expression between the Lean and Fat mice in liver genes
Gene name | Gene Symbol | GeneBank Code | Log2 ratio* | L:F** |
|---|---|---|---|---|
Cholesterol metabolism | ||||
Mevalonate kinase | Mvk | NM_023556 | 0.11 | ↑ |
NAD(P) dependent steroid dehydrogenase-like | Nsdhl | BC019945 | 0.15 | ↑ |
Sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) | Sc5d | BC024132 | 0.27 | ↑ |
Mevalonate (diphospho) decarboxylase | Mvd | NM_138656 | 0.29 | ↑ |
Lanosterol synthase | Lss | NM_146006 | 0.33 | ↑ |
Farnesyl diphosphate synthetase | Fdps | NM_134469 | 0.41 | ↑ |
Farnesyl diphosphate farnesyl transferase 1 | Fdft1 | NM_010191 | 0.44 | ↑ |
Acyl-CoA synthetase short-chain family member 2 | Acss2 | NM_019811 | 0.36 | ↑ |
Bile acid and glucose metabolism | ||||
Glucose-6-phosphatase, catalytic | G6Pc | NM_008061 | -1.01 | ↓ |
Pyruvate dehydrogenase (lipoamide) beta | Pdhb | NM_024221 | -0.28 | ↓ |
Solute carrier organic anion transporter family, member 1a4 | Slco1a4 | NM_030687 | -0.71 | ↓ |
Solute carrier organic anion transporter family, member 1a1 | Slco1a1 | AY195868 | -0.49 | ↓ |
Solute carrier organic anion transporter family, member 1b2 | Slco1b2 | NM_020495 | -0.36 | ↓ |
Solute carrier family 10 (sodium/bile acid cotransporter family), member 1 | Slc10a1 | BC094023 | -0.13 | ↓ |
ATP-binding cassette, sub-family G (WHITE), member 5 | Abcg5 | NM_031884 | -0.15 | |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 | Abcb11 | NM_021022 | 0.65 | ↑ |
Cytochrome P450, family 8, subfamily b, polypeptide 1 | Cyp8b1 | NM_010012 | 0.52 | ↑ |
Drug metabolism | ||||
Cytochrome P450, family 2, subfamily a, polypeptide 5 | Cyp2a5 | BC011233 | -0.52 | ↓ |
Cytochrome P450, family 2, subfamily b, polypeptide 10 | Cyp2b10 | AK028103 | -0.44 | ↓ |
Cytochrome P450, family 2, subfamily b, polypeptide 9 | Cyp2b9 | NM_010000 | -0.38 | ↓ |
Cytochrome P450, family 2, subfamily b, polypeptide 9 | Cyp2b9 | NM_007813 | -0.38 | ↓ |
Cytochrome P450, family 3, subfamily a, polypeptide 41A | Cyp3a41a | NM_017396 | -0.37 | ↓ |
Cytochrome P450, family 2, subfamily c, polypeptide 69 | Cyp2c69 | NM_010004 | 0.34 | ↑ |
Cytochrome P450, family 1, subfamily a, polypeptide 2 | Cyp1a2 | NM_009993 | 0.41 | ↑ |
Others | ||||
Complement component 9 | C9 | BC011137 | -1.37 | ↓ |
Serum amyloid P-component | Apcs | BC061125 | 0.46 | ↑ |
Complement component 4B (Childo blood group) | C4b | BC067409 | 1.55 | ↑ |
C-reactive protein, pentraxin-related | Crp | NM_007768 | 0.25 | ↑ |
Orosomucoid 1 | Orm1 | BC012725 | -0.34 | ↓ |
Hemopexin | Hpxn | BC019901 | 0.12 | ↑ |
Nuclear receptor subfamily 5, group A, member 2 (LRH-1) | Nr5a2 | NM_030676 | 0.16 | ↑ |
Acetyl-Coenzyme A acetyltransferase 2 | Acat2 | NM_009338 | 0.22 | ↑ |
Apolipoprotein A-II | Apoa2 | BC031786 | 0.23 | ↑ |
Lysosomal acid lipase A | Lip1 | NM_021460 | 0.23 | ↑ |
Low density lipoprotein receptor | Ldlr | BC019207 | 0.27 | ↑ |
Insulin induced gene 1 | Insig1 | NM_153526 | 0.33 | ↑ |
Nitric oxide synthase 1, neuronal | Nos1 | BC066101 | 0.34 | ↑ |
Adiponectin receptor 2 | Adipor2 | NM_197985 | 0.35 | ↑ |